不同海拔高度人群胃蛋白酶原血清水平差异性分析  

Analysis on Variations of Serum Pepsinogen in Different Altitude Population

作　　者：胡娟[1] 徐鹏[1] 呼永河[2] 林薇[3] 

机构地区：[1]成都军区临床医学检验中心,成都610083 [2]成都军区总医院,成都610083 [3]第三军医大学研究生管理大队,重庆400038

出　　处：《现代检验医学杂志》2015年第3期32-34,共3页Journal of Modern Laboratory Medicine

基　　金：国家高技术研究发展计划（“863”计划,2006AA020905）;全军医学科技“十二五”重点项目（BWS11J067）.

摘　　要：目的：了解在不同海拔高度人群血清中胃蛋白酶原（pepsinogen，PG）含量的变化情况。方法采集不同海拔地区人群的血液标本进行 PG 血清含量检测，根据海拔高度不同进行分组比较，PGR 为 PGI 与 PGII 的比值，对检测数据比较采用独立样本 t 检验。结果1000米组 PGI，PGII 和 PGR 结果数据分别为136.892±2.64μg／L，10.05±5.14μg／L 和13.07±7.41，与1300米组（分别为130.87±48.66μg／L，11.55±2.78μg／L 和12.89±4.76）比较 PGI 与 PGII 差异有统计学意义（P ＜0.05），而 PGR 差异无统计学意义（P ＞0.05）；1500米组上述各项数据分别是126.64±29.84μg／L，12.18±5.99μg／L 和12.2±14.84，与1000米组及1300米组比较 PGI 与 PGII 差异均有统计学意义（P ＜0.05），PGR 差异无统计学意义（P ＞0.05）；其中 PGI 血清水平与海拔高度呈负相关，PGII 血清水平与海拔呈正相关。结论研究发现随着海拔的升高人们的 PGI 血清含量会降低，而人 PGII 的血清含量会随海拔升高而升高，该海拔地区的氧分压不同可能是影响PG 水平变化的主要原因。Objective To compare the serum pepsinogen （PG）in different altitude population.Methods By testing serum PG of people from different altitudes,detected the concentration of serum PG.Results The serum PGI,serum PGII and PGR were respectively 136.89±22.64 μg/L,10.05 ± 5.14 μg/L and 13.07 ± 7.41 in 1 000 m group,and they were 30.87 ± 48.66 μg/L,11.55±2.78 μg/L and 12.89±4.76 in 1 300 m group.There were significant difference in PGI and PGII（P 〈0.05）except PGR （P 〉0.05）between the two groups.The corresponding indices in 1500m group （126.64±29.84 μg/L, 12.18±5.99 μg/L and 12.2±14.84,respectively）,the serum PGI was decreased obviously compared with those groups （P〈0.05）,the serum PGII was increased obviously compared with those groups （P 〈 0.05）,No significant difference was found when compared with those groups （P 〉0.05）.The serum PGI was negative correlated with higher altitudes,the ser-um PGII was positively correlated with higher altitudes.Conclusion The study found that the serum PGI content would re-duce with the increase of altitude,and on the contrary the serum PGII would rise with the increase of altitude.The main rea-son that the serum PG change may be influenced by oxygen partial pressure.

关 键 词：胃蛋白酶原 高原 氧分压 胃病 

分 类 号：R446.112[医药卫生—诊断学]