男性2型糖尿病病人骨密度变化及其相关影响因素  

BONE DENSITY AND ITS INFLUENCING FACTORS IN MALE PATIENTS WITH TYPE 2 DIABETES

作　　者：毛桂芝 韩琳[1] 姜爱卿[2] 李长贵[1] 贾兆通[1] 

机构地区：[1]青岛大学附属医院代谢性疾病科,山东青岛266003 [2]青岛大学附属医院内科门诊,山东青岛266003

出　　处：《青岛大学医学院学报》2015年第3期267-269,273,共4页Acta Academiae Medicinae Qingdao Universitatis

基　　金：国家自然科学基金资助项目(81100621);山东省自然科学基金资助项目(ZR2011HM005)

摘　　要：目的 探讨男性2型糖尿病病人骨密度的变化及其影响因素。方法 采用美国QDR 4500W型双能量X线骨密度仪测定66例男性2型糖尿病病人和53例男性健康体检者第1~4腰椎（L1、L2、L3、L4、L1~4总体）及左侧髋部（股骨颈、大转子、Ward三角、股骨干、左髂骨总体）骨密度,同时记录受试者年龄、病程,测定身高、体质量、腰围、臀围、糖化血红蛋白（HbA1c）、空腹C肽、餐后2hC肽等指标,多元回归分析男性2型糖尿病病人骨密度的影响因素。结果 两组各部位骨密度比较差异均无显著性（P〉0.05）。多元回归分析显示,男性2型糖尿病病人L1~4总体和左髂骨总体骨密度与HbA1c呈负相关（β=-0.302、-0.256,P〈0.05）。结论 男性2型糖尿病病人骨密度可以是正常的,并且与HbA1c关系密切。Objective To explore the bone mineral density （BMD） and its influencing factors in male patients with type 2 diabetes mellitus （T2DM）. Methods Using dual-energy X-ray absorptiometry （DXA）, 66 male patients with T2MD and 53 healthy male controls were detected for their bone density as follows= lumbar spine 1-4 and left hip-including femur neck,greater trochanter,Ward trlangle,shaft of femur, and left ilium. The patient age, course of disease, height, weight, waistline, hip circum- ference, serum HbAlc, fasting C petide （FCP）, and 2-hour postprandial C-petide were recorded. Influencing factors of bone densi- ty of the patients were analyzed by employing multivariate regression analysis. Results The differences of BMD between the two groups were not significant （P〉0.05）. Multivariate regression analysis showed the BMD of L1-4 and left ilium in the patients was negatively correlated with HbA1c （β= -0.302,-0.256;P〈0.05）. Conclusion Bone mineral density of male patients with type 2 diabetes mellitus can be normal and closely associated with HbA1e.

关 键 词：糖尿病 2型 骨密度 因素分析 统计学 

分 类 号：R587.1[医药卫生—内分泌]