瘦素和胰岛素样生长因子-1与小于胎龄儿生长发育的关系  

Relationship between leptin,insulin-like growth factor-1 and growth development of small for gestational age infants

作　　者：刘芳[1] 林广[1] 刘改英[1] 付如婷 郭锐[1] 

机构地区：[1]珠海市人民医院儿科,广东珠海519020

出　　处：《新乡医学院学报》2015年第6期570-571,共2页Journal of Xinxiang Medical University

基　　金：珠海市卫生局科技计划项目(编号:2005001)

摘　　要：目的探讨瘦素和胰岛素样生长因子-1(IGF-1)与小于胎龄儿(SGA)生长发育的关系。方法选择2011年8月至2013年12月在珠海市人民医院出生的足月新生儿80例,分为SGA组和适于胎龄儿(AGA)组,每组40例。测量新生儿出生体质量、身长、头围。应用放射免疫分析法测定2组新生儿脐血瘦素及IGF-1水平。结果 SGA组新生儿体质量、身长、头围均显著低于AGA组(P<0.05),血清瘦素、IGF-1水平亦显著低于AGA组(P<0.01)。瘦素和IGF-1水平均与出生体质量、身长呈显著正相关(P<0.05),而血清瘦素与IGF-1无明显相关性(P>0.05)。结论瘦素和IGF-1在胎儿生长发育中起重要作用,与新生儿的出生体质量和身长有关。Objective To explore the relationship between leptin,insulin-like growth factor-1（ IGF-1） and growth development of small for gestational age（ SGA） infants. Methods A total of 80 full-term newborns in Zhuhai People＇s Hospital from August 2011 to December 2013 were selected,and were divided into SGA group and appropriate for gestational age infant（AGA group） with 40 cases in each group. The birth weight,birth length and head circumference of the infants in the two groups were measured. The levels of cord blood leptin,IGF-1 in the two groups were examined by radio immunoassay. Results The birth weight,birth length and head circumference in SGA group were significantly lower than those in AGA group（ P〈0. 05）. The levels of cord blood leptin,IGF-1 in SGA group were significantly lower than those in SGA group（ P〈0. 01）. The levels of cord blood leptin and IGF-1 were positively correlated with the birth weight and length. But there was no obvious correlation between leptin and IGF-1. Conclusion Leptin and IGF-1 play important roles in the growth development of fetus,which have correlation with neonatal birth weight and length.

关 键 词：小于胎龄儿 瘦素 胰岛素样生长因子-1 生长发育 

分 类 号：R723[医药卫生—儿科]