血清可溶性髓细胞触发受体-1和降钙素原对围生期宫内感染合并肺炎新生儿肺出血的影响  

Effects of Combination of Pneumonia Infection in Neonatal Pulmonary Hemorrhage

作　　者：郭笑芳[1] 卢燕玲[1] 丁月琴[1] 

机构地区：[1]东莞市人民医院儿科二区,广东东莞523000

出　　处：《中国药物经济学》2015年第6期89-91,共3页China Journal of Pharmaceutical Economics

摘　　要：目的探讨血清可溶性髓细胞触发受体-1(s TREM-1)和降钙素原(PCT)对围生期宫内感染合并肺炎新生儿肺出血(NPH)的影响。方法收集48例NPH患儿(观察组)和50例非肺出血患儿(对照组),采用酶联免疫吸附试验(ELISA)检测血清s TREM-1含量,放射免疫分析法检测血清PCT含量。统计学分析血清s TREM-1和PCT含量与NPH患儿原发病类型及母体围产期疾病的关系。结果 NPH患儿血清s TREM-1和PCT含量均高于非肺出血患儿;原发病为肺炎NPH患儿血清s TREM-1含量明显高于原发病为缺血缺氧性脑病、颅内出血、呼吸窘迫综合征和寒冷损伤综合征等患儿;母体围产期发生宫内感染NPH患儿血清s TREM-1和PCT含量均高于母体围生期发生妊娠高血压综合征、羊水早破、胎盘早剥及糖尿病NPH患儿(均P<0.05);NPH患儿血清s TREM-1含量和PCT含量明显呈正相关(P<0.01)。结论 s TREM-1和PCT检测可能对原发病为肺炎伴母体围生期发生宫内感染的NPH患儿具有预警价值。Objective To investigate the serum levels of soluble triggering receptor expressed on myeloid cells-l（sTREM-1）and procalcitonin（PCT）on perinatal intrauterine infection complicated with pneumonia in neonatal pulmonary hemorrhage（NPH） effect.Methods Collected from 48 NPH patients（observation group）and 50 cases with pulmonary hemorrhage（control group）,Use the content of sTREM-1 in serum ELISA detection and analysis of serum PCT contents were detected by radioimmunoassay.Statistical analysis the relationship between the primary disease types and maternal perinatal diseases,serum sTREM-1 and PCT levels in children with NPH.Results Serum sTREM-1 and PCT levels on NPH patients were higher than those of non-pulmonary hemorrhage.In NPH patients, serum sTREM-1 levels on primary disease onset from pneumonia were significantly higher than those onsets from Hypoxic- ischemic encephalopathy, intracranial hemorrhage,respiratory distress syndrome and cold injury syndrome, and serum sTREM^I and PCT levels on mother with perinatal intrauterine infection were significantly higher than those mother with Preeclampsia,premature rupture of the amniotic fluid（P〈0.05）,placental abruption and diabetes, respectively. Serum sTREM-1 content was significantly positively correlated with PCT content on NPH patients （P〈0.01）. Conclusion Serum sTREM-1 and PCT levels may have a warning value for neonatal pulmonary hemorrhage patients with perinatal intrauterine infection and pneumonia.

关 键 词：新生儿肺出血 宫内感染 肺炎 血清髓细胞触发受体1 降钙素原 

分 类 号：R725[医药卫生—儿科]