丹参注射液联合小剂量阿司匹林对妊娠期高血压疾病患者氧自由基和血管内皮细胞功能的影响研究  

Study on the effect of salvia injection combined with low-dose aspirin on oxygen free radicals and vascular endothelial cell function of patients with hypertensive disorder complicating pregnancy

作　　者：郑晓瑛[1] 姚静[1] 朱加美 李梅[1] 邱淑琼 朱兆霞[1] 张明[1] 

机构地区：[1]山东省诸城市妇幼保健院妇产科,262200

出　　处：《中国妇幼保健》2015年第18期2920-2922,共3页Maternal and Child Health Care of China

基　　金：中国疾病预防控制中心妇幼保健中心妇幼保健分子遗传医学研究专项〔FY-ZX-ZD-196〕

摘　　要：目的:探讨丹参注射液联合小剂量阿司匹林对妊娠期高血压疾病患者氧自由基和血管内皮细胞功能的影响。方法:将192例妊娠期高血压疾病患者随机分为两组,每组96例。对照组给予常规治疗,观察组在对照组基础上给予丹参注射液联合小剂量阿司匹林治疗。两组均治疗10天。治疗前后对两组平均动脉压(MAP)、24 h尿蛋白(24 h Upro)、一氧化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MDA)、内皮素-1(ET-1)水平进行检测,并对两组母儿结局进行统计。结果:治疗后,两组MAP、24 h Upro、MDA、ET-1水平显著降低,差异有统计学意义(P<0.05),且观察组MAP、24 h Upro、MDA、ET-1水平明显低于对照组,差异有统计学意义(P<0.05)。两组SOD、NO水平显著增大,差异有统计学意义(P<0.05),且观察组SOD、NO水平明显高于对照组,差异有统计学意义(P<0.05)。观察组胎心异常、新生儿窒息、剖宫产率均显著低于对照组,差异有统计学意义(P<0.05)。结论:丹参注射液联合小剂量阿司匹林对妊娠期高血压疾病疗效确切,其作用机制可能是通过调控氧自由基和改善血管内皮功能实现。Objective： To explore the effect of salvia injection combined with low- dose aspirin on oxygen free radicals and vascular endothelial cell function of patients with hypertensive disorder complicating pregnancy（ HDCP）. Methods： A total of 192 patients with HDCP were randomly divided into two groups,96 patients in each group. The patients in control group were given conventional treatment,and the patients in observation group were given salvia injection combined with low- dose aspirin based on conventional treatment. The patients in the two groups were treated for 10 days. Before and after treatment,mean arterial pressure（ MAP）,24- hour urine protein（ 24 h Upro）,nitric oxide（ NO）,superoxide dismutase（ SOD）,malondialdehyde（ MDA）,and endothelin- 1（ ET- 1） levels in the two groups were detected,and maternal and infantile outcomes in the two groups were statistically analyzed. Results： After treatment,MAP,24 h Upro,MDA,and ET- 1 levels in the two groups decreased significantly（ P〈0. 05）,especially in observation group（ P〈0. 05）. After treatment,SOD and NO levels in the two groups increased significantly（ P〈0. 05）,especially in observation group（ P〈0. 05）. The incidence rates of abnormal fetal heart and neonatal asphyxia,and cesarean section rate in observation group were statistically significantly lower than those in control group（ P〈0. 05）. Conclusion： Salvia injection combined with low- dose aspirin can effectively treat HDCP,and its mechanism may be related to the regulation of oxygen free radicals and improvement of vascular endothelial cell function.

关 键 词：妊娠期高血压疾病 丹参注射液 小剂量阿司匹林 作用机制 

分 类 号：R714[医药卫生—妇产科学]