瘦素和瘦素受体在重度子宫内膜异位症伴不孕患者在位内膜和异位内膜的表达  

Expressions of leptin and leptin receptor in eutopic endometrium and ectopic endometrium of patients with severe endometriosis combined with infertility

作　　者：刘霓[1] 徐园园[2] 谢咏[1] 韩玉斌[1] 

机构地区：[1]广东省佛山市第一人民医院妇产科,528000 [2]广东省佛山市第一人民医院病理科

出　　处：《中国妇幼保健》2015年第18期3022-3025,共4页Maternal and Child Health Care of China

摘　　要：目的:探讨瘦素和瘦素受体在重度子宫内膜异位症伴不孕患者在位内膜和异位内膜的表达及在重度子宫内膜异位症伴不孕症发病机制的作用。方法:采用免疫组化方法测定重度子宫内膜异位症伴不孕组32例与子宫内膜正常对照组30例在位内膜和异位内膜瘦素和瘦素受体的表达。结果:瘦素在腺上皮细胞的表达:在位内膜、对照组内膜的表达高于异位内膜,差异有统计学意义(P<0.05);在位内膜与对照组内膜的表达差异无统计学意义(P>0.05)。瘦素受体在腺上皮细胞的表达:异位内膜、在位内膜及对照组内膜的表达差异无统计学意义(P>0.05)。结论:重度子宫内膜异位症不孕患者在位内膜超微结构的改变及内膜容受性的降低其瘦素及瘦素受体系统起的作用有限。Objective： To explore the expressions of leptin and leptin receptor in eutopic endometrium and ectopic endometrium of patients with severe endometriosis combined with infertility and the roles of leptin and leptin receptor in pathogenesis of severe endometriosis combined with infertility. Methods： Immunohistochemical method was used to detect the expressions of leptin and leptin receptor in eutopic endometrium and ectopic endometrium of 32 patients with severe endometriosis combined with infertility（ case group） and normal endometrium in 30 healthy women（ control group）. Results： The expression levels of leptin receptor in glandular epithelial cells of eutopic endometrium in case group and normal endometrium in control group were statistically significantly higher than those in ectopic endometrium in case group（ P〈0. 05）; there was no statistically significant difference between eutopic endometrium in case group and normal endometrium in control group（ P〉0. 05）. There was no statistically significant difference in the expression level of leptin in glandular epithelial cells among eutopic endometrium and ectopic endometrium in case group and normal endometrium in control group（ P〉0. 05）. Conclusion： The roles of leptin and leptin receptor in the changes of microstructure of eutopic endometrium and decrease of endometrial receptivity are limited among the patients with severe endometriosis combined with infertility.

关 键 词：子宫内膜异位症 瘦素 瘦素受体 在位内膜 异位内膜 

分 类 号：R711.71[医药卫生—妇产科学]