三种积分系统评估骨髓增生异常综合征预后的价值  

THE VALUE OF IPSS-R,WPSS AND WDAPSS SCORING SYSTEMS FOR PROGNOSTIC ASSESSMENT OF MYELODYSPLASTIC SYNDROME

作　　者：燕敬茹[1] 黄涛生[2] 崔景英[2] 徐文君[2] 任翠爱[2] 

机构地区：[1]潍坊医学院,血液病学专业山东潍坊261042 [2]潍坊市人民医院血液科

出　　处：《齐鲁医学杂志》2015年第3期270-272,共3页Medical Journal of Qilu

摘　　要：目的比较IPSS-R、WPSS和WDAPSS三种积分系统评估骨髓增生异常综合征（MDS）预后的价值。方法回顾性分析潍坊市人民医院收治的80例MDS病人的临床及实验室检查资料，应用Kaplarl-Meier方法绘制生存曲线，各积分系统按照危险度对MDS病人进行分组，比较各积分系统不同组的生存期。结果各积分系统不同组的生存期差异均有统计学意义（χ2=30．532～56．710，P〈0.01）。IPSS-R与WPSS相关性最强（r=0．870，P〈0．01），WDAPSS与WPSS相关性次之（r=0．807，P〈0．01），IPSS-R与WDAPSS相关性较差（r=0．715，P〈0.01）。结论三种积分系统均能较好预测MDS病人的预后，综合运用不同的积分系统将病人分组，有助于早期评估MDS病人预后。Objective To compare the value of IPSS-R, WPSS and WDAPSS scoring systems in predicting the prognosis of myelodysplastic syndrome （MDS）. Methods The clinical and laboratory data of 80 patients with MDS treated in Weifang People＇s Hospital were retrospectively reviewed. Using Kaplan Meier method, a survival curve was made. The three score systems were used to divide the patients into several groups according to the risk factor. The life span in patients between each scoring system was compared. Results The difference of life span between different groups was statistically significant （χ2=30.532-- 56.710,P〈0.01）. IPSS-R was most strongly correlated with WPSS （r=0.870,P〈0.01）, followed by WDAPSS and WPSS （r= 0.807,P〈0.01）, and IPSS-R and WDAPS （r=0.715,P〈0.01）. Conclusion All the three scoring systems can better predict the prognosis of patients with myelodysplastic syndrome. Integrated use of different scoring system to divide patients into several groups is conducive to early prediction of prognosis of patients with this condition.

关 键 词：骨髓增生异常综合征 IPSS-R积分系统 WPSS积分系统 WDAPSS积分系统 预后 

分 类 号：R551.3[医药卫生—血液循环系统疾病]