星点设计-效应面法优化葛根黄酮固体脂质纳米粒处方  

Optimization of the Formula for Puerarin Flavonoids Solid Lipid Nanoparticle by Central Design- Response Surface Method

作　　者：张广远[1] 孙士淋 刘昕[1] 樊红波[1] 王玉[1] 管清香[1] 

机构地区：[1]吉林大学药学院,长春130021

出　　处：《特产研究》2015年第2期9-11,22,共4页Special Wild Economic Animal and Plant Research

基　　金：吉林省科技厅项目(20130206049YY);吉林省中医药管理局项目(2010-112)

摘　　要：采用星点设计-效应面法优化葛根黄酮纳米粒处方。以脂质硬脂酸、乳化剂泊洛沙姆188及大豆卵磷脂用量为因变量,以包封率为应变量,溶剂扩散法制备葛根黄酮固体脂质纳米粒。结果表明,二项拟合方程优于多元线性回归方程,脂质硬脂酸最佳范围为0.50g^0.65g,乳化剂泊洛沙姆188最佳范围为0.125g^0.140g,大豆卵磷脂最佳范围为0.25g^0.45g。结果证实,此范围内制得纳米粒包封率与预测值较为接近,拟合方程可较好预测实验结果。Central design-response surface method was employed to optimize the formula of puerarin flavonoids solid lipid nanoparticle （PF-SLN ） .Dosages of stearic acid ,poloxamer 188 and soybean lecithin were chosen as independent variables ,entrapment efficiency was selected as dependent variable solvent ,injection method was used to prepare PF-SLN .The results showed that binomial fitting equations of indexes were all superior to that of multi-linear regression equations .The optimal dosage of stearic acid ,poloxamer 188 and soybean lecithin were 0.50g-0.65g ,0.125g-0.14g ,0.25g-0.45g respectivel .The predictive values of entrapment efficiency were in conformity with the experimental values well .

关 键 词：葛根黄酮 星点设计 固体脂质纳米粒 

分 类 号：R943[医药卫生—药剂学]