烧伤感染后血清补体C3IL-10的变化  

Study on the changes of serum complement C3and IL-10m after burn injury and infection

作　　者：高敏[1] 刘鲲[2] 刘宁[2] 戴军[2] 王文军[2] 

机构地区：[1]济宁医学院附属济宁市第一人民医院,山东济宁272011 [2]济宁医学院第一临床学院,济宁272067

出　　处：《济宁医学院学报》2015年第3期168-170,共3页Journal of Jining Medical University

摘　　要：目的探究机体烧伤感染后免疫因子的水平变化。方法选取2013年4月至2014年2月我院收治的200例烧伤患者,分别于烧伤后第3、7、14天检测观察外周血补体C3、IL-10水平并进行比较。结果随着时间的推移,患者创面感染率升高;烧伤后患者补体C3和IL-10的水平均呈现先上升后下降的变化;感染患者体内的补体C3水平均高于未感染患者;烧伤后脓毒血症患者机体补体C3和IL-10水平均高于单独创面感染患者。结论烧伤后感染可影响患者血清补体C3和IL-10水平的改变,可通过对相应免疫因子水平的调节进行治疗以维持患者体内免疫反应平衡,防止感染加重。Objective To explore the changes of serum complement C3 and IL‐10 after the burn infection .Meth‐ods Burn patients were selected from April 2013 to February 2014 in our hospital ,and the levels of serum comple‐ment C3 and IL‐10 in the peripheral blood were detected on days 3 ,7 ,14 after burns .Results Wound infection rate of patients elevated in a time‐dependent manner .Complement factor C3 and IL‐10 levels of all patients increased then declined after burn .Complement C3 levels of infected patients were higher than those of uninfected patients in different periods .Complement C3 and IL‐10 levels of sepsis patients were higher than those of patients with a single wound infection at different periods .The results have statistically significant （ P〈0.05） .Conclusion Burn infec‐tion can affect the serum levels of immune factors .We can regulate levels of immune factors in order to maintain immune balance and prevent the aggravation of infection .

关 键 词：烧伤 感染 免疫因子 脓毒血症 

分 类 号：R392.7[医药卫生—免疫学]