高效抑菌性能的聚乳酸/银纳米纤维的制备及生物特性  

Preparation of Highly Efficient Antibacterial Poly(lactic acid)/Ag Nanofibers and Its Biological Properties

作　　者：张硕[1] 杨凤[1] 何晓峰[1] 张贺新[2] 张学全[2] 

机构地区：[1]沈阳化工大学材料科学与工程学院,辽宁沈阳110142 [2]中国科学院长春应用化学研究所,吉林长春130022

出　　处：《沈阳化工大学学报》2015年第2期149-153,共5页Journal of Shenyang University of Chemical Technology

摘　　要：通过对聚乳酸和银纳米粒子的1,1,1,3,3,3-六氟代-2-丙醇（HFIP）溶液进行静电纺丝,制备具有不同银粒子浓度的聚乳酸/银纳米纤维材料,并对其进行细胞活性及抗菌性等方面的测定.研究发现：制备的聚乳酸/银纳米纤维直径分布在200~600 nm之间,银纳米粒子在纤维内分散均匀,无团聚发生,当银纳米颗粒质量分数为0.2%时,即具备优良的抗菌杀菌性能（杀菌性〉99%）,同时纤维材料保持了良好的细胞相容性.In this research,poly（ L-lactide） / Ag nanofibers containing different concentrations of Ag nanoparticles were prepared by electrospining a blend solution of poly（ L-lactide） and silver nanoparticles in 1,1,1,3,3,3-hexafluoro-2-propanol（ HFIP）. The cell viability and antibacterial activity of the resultant nanofibers were investigated. According to the results,the diameter of the resulting nanofibers was in the range from 200 to 600 nm and the Ag nanoparticles were well dispersed（ without aggregate）. In addition,the poly（ L-lactide） / Ag nanofibers exhibited excellent cell compatibility and significant antibacterial ability only containing small amount（ 0. 2 %） of Ag nanoparticles.

关 键 词：聚乳酸 银纳米颗粒 纳米纤维 生物材料 

分 类 号：O631[理学—高分子化学]