冠心病患者血浆纤维蛋白原水平与肺功能相关性分析  

Correlation between pulmonary function and plasma fibrinogen in patients with coronary heart disease

作　　者：陈一冰[1] 曹璐[1] 郝峰英[1] 陈良安[1] 

机构地区：[1]解放军总医院呼吸科肺功能室,北京100853

出　　处：《解放军医学院学报》2015年第7期658-660,712,共4页Academic Journal of Chinese PLA Medical School

摘　　要：目的通过研究冠心病患者血浆纤维蛋白原（plasma fibrinogen,PF）和肺功能的相关性,探讨冠心病（coronary heart disease,CHD）对肺功能的影响。方法选取2013年8月-2014年10月于本院心外科住院且术前诊断为冠心病的患者220例,男163例,女57例,年龄26~83岁。患者均完成肺功能检查,静脉取血行实验室检查。分组比较血浆纤维蛋白原和肺功能指标的相关性。结果男性冠心病患者PF与一秒量（forced expiratory volume in one second,FEV1%）、用力肺活量（forced vital capacity,FVC%）、肺活量（vital capacity,VC%）、肺一氧化碳弥散量（diffusion capacity of the lung for carbon monoxide,DLCO%）等指标均呈负相关。肺弥散功能（DLCO%）正常与异常组的血浆纤维蛋白原水平存在差异。结论男性冠心病患者的PF水平与肺功能指标显著相关,PF水平可能成为一项男性冠心病患者肺功能损害的预测指标。冠心病患者中,弥散功能的下降可能与血浆纤维蛋白原水平升高有关。Objective To study the relationship between pulmonary function and plasma fibrinogen （PF） in patients with coronary heart disease （CHD）, and investigate the effects of CHD on pulmonary function. Methods Clinical data about 220 CHD patients （163 males and 57 females, age range from 26 to 83 years） admitted to our department from August 2013 to October 2014 were collected. Venous blood samples were taken for laboratory testing. Pulmonary function was measured by our pulmonary function technicians. Patients were divided into groups by sex and pulmonary function. The relationship of PF level and pulmonary function was analyzed. Results In male CHD patients, PF was negatively related to forced expiratory volume in one second （FEV1%）, forced vital capacity （FVC%）, vital capacity （VC%）, diffusion capacity of the lung for carbon monoxide （DLCO%）. The DLCO% and PF in abnormal lung function group showed significant difference （P=0.011）. Conclusion In male CHD patients, PF level is significantly related to pulmonary function and may be a predictor of pulmonary dysfunction. Rising of PF level may result in reduction of lung diffusing capacity.

关 键 词：冠心病 肺功能 血浆纤维蛋白原 相关性分析 

分 类 号：R541.4[医药卫生—心血管疾病]