Composite bioabsorbable vascular stents via 3D bio-printing and electrospinning for treating stenotic vessels  

结合生物3D打印和静电纺丝制备复合生物可吸收血管支架用于血管狭窄治疗（英文）

作　　者：刘媛媛[1,2] 向科[1] 李瑜[1] 陈海萍[1] 胡庆夕[1,2] 

机构地区：[1]上海大学快速制造工程中心,上海200444 [2]上海大学上海市智能制造及机器人重点实验室,上海200072

出　　处：《Journal of Southeast University(English Edition)》2015年第2期254-258,共5页东南大学学报（英文版）

基　　金：The National Natural Science Foundation of China(No.51475281,51375292);the National Natural Science Foundation for Young Scholar of China(No.51105239)

摘　　要：A new type of vascular stent is designed for treating stenotic vessels. Aiming at overcoming the shortcomings of existing equipment and technology for preparing a bioabsorbable vascular stent （BVS）, a new method which combines 3D bio-printing and electrospinning to prepare the composite bioabsorbable vascular stent （CBVS） is proposed. The inner layer of the CBVS can be obtained through 3D bio- printing using poly-p-dioxanone （PPDO）. The thin nanofiber film that serves as the outer layer can be built through electrospinning using mixtures of chitosan-PVA （poly （vinyl alcohol））. Tests of mechanical properties show that the stent prepared through 3D bio-printing combined with electrospinning is better than that prepared through 3D bio- printing alone. Cells cultivated on the CBVS adhere and proliferate better due to the natural, biological chitosan in the outer layer. The proposed complex process and method can provide a good basis for preparing a controllable drug-carrying vascular stent. Overall, the CBVS can be a good candidate for treating stenotic vessels.设计一种新型血管支架用于血管狭窄治疗.针对目前制备生物可吸收血管支架(BVS)在装备和技术上的不足,提出了结合生物3D打印和静电纺丝制备复合生物可吸收血管支架(CBVS)的新方法.首先,用PPDO材料通过3D打印制备支架内层;然后,配制壳聚糖和PVA混合溶液,通过静电纺丝制备支架外层.力学性能测试显示,结合3D打印和静电纺丝制备的支架要好于仅采用3D打印制备的支架.在支架上种植细胞试验表明,细胞在支架上有良好的粘附和增殖,因为外层含有天然生物材料壳聚糖.所提出的复合成形工艺和方法,为后续构建可控携载药物支架提供了很好的思路.该CBVS可用于血管狭窄治疗.

关 键 词：3D （ three-dimensional ） bio-printing bioabsorbable vascular stent （BVS） ELECTROSPINNING CELLPROLIFERATION composite forming 

分 类 号：TH16[机械工程—机械制造及自动化]