老年高血压心室肥厚并心房颤动患者血浆脑钠肽水平的变化及意义  

Changes and significance of Plasma brain natriuretic peptide in elderly hypertension with left ventricular hypertrophy and atrial fibrillation

作　　者：刘艳丽[1] 陶新智[1] 孙世玲[1] 

机构地区：[1]广西医科大学第一附属医院老年心内科,广西南宁530021

出　　处：《蛇志》2015年第2期126-127,共2页Journal of Snake

基　　金：广西壮族自治区卫生厅自筹经费项目(Z2011319)

摘　　要：目的探讨老年高血压左室肥厚合并持续性心房颤动与血浆B型脑钠肽（BNP）水平的关系。方法选择2011年1月~2012年12月我院住院及门诊的老年高血压患者106例,对其中48例有持续性心房颤动的老年高血压左室肥厚患者（A组）的血浆BNP水平、左室间隔厚度（IVS）、左房内径（LAD）和左室射血分数（LVEF）进行检测,并与其中30例无房颤病史的高血压心室肥厚（B组）患者及28例单纯高血压（C组）患者进行比较。结果在3组患者左房内径无差异的情况下,合并房颤老年高血压患者血浆BNP水平显著高于无房颤病史者,且随左室肥厚程度加重而升高。结论高血压左室肥厚合并持续性房颤患者的BNP水平明显升高。BNP水平可作为预测高血压左室肥厚患者房颤发生的危险因素。Objective To explore whether persistent atrial fibrillation of patients with essential hypertension could be identified by plasma levels of brain natriuretic peptide（BNP）. Methods The plasma levels of brain natriuretic peptide（BNP）were measured,both 48 essential hypertensive patients with persisitent atrial fibrillation,30 essential hypertensive and left ventricular hypertrophy patients without atrial fibrillation and 28 essential hypertensive patients.Ventricular septal thickness（IVS）,left atria diameter（LAD）and left ventricular ejection fraction（LVEF）were measured by echocardiogryphy. Results Plasma levels of BNP,was significantly higher in group At than those in group B and group C. Conclusion Plasma levels of BNP may be prediction of the risk of developing persistent atrial fibrillation in essential hypertensive patients.

关 键 词：高血压 左室肥厚 心房颤动 B型脑钠肽 

分 类 号：R544.1[医药卫生—心血管疾病] R541.75[医药卫生—内科学]