无溶剂氧化亚锡催化合成2-[(3-吲哚基)-甲基]丙二酸二甲酯衍生物  

Sn O Catalyzed Solvent-Free Synthesis of Dimethyl 2-[( Indol-3-yl)-methyl]malonate Derivatives

作　　者：许招会[1] 

机构地区：[1]江西师范大学化学化工学院,南昌330027

出　　处：《应用化学》2015年第7期759-764,共6页Chinese Journal of Applied Chemistry

基　　金：国家科技攻关计划(2001BA323C);江西省研究生创新基金(YC10A51)资助项目~~

摘　　要：在氧化亚锡催化下,吲哚、醛和丙二酸二甲酯在无溶剂条件下三组分反应合成了10种2-[（3-吲哚基）-甲基]丙二酸二甲酯衍生物。反应无溶剂污染,反应条件温和,收率为58%-74%。讨论了反应速度与取代基的关系,探讨了可能的缩合反应机理,并应用^1H NMR、^13C NMR、IR等技术手段确定了产品的结构。Ten dimethyl 2-[ （indol-3-yl） -methyl] malomate derivatives were synthesized by three-component one-pot reaction of indole with aldehydes and dimethyl malonate under solvent-free condition in the presence of SnO as the catalyst. The yields ranged from 58% to 74%. The advantages of this method are no solvent pollution and mild reaction conditions. Furthermore, a mechanism for this condensation reaction was proposed and the relationship between reaction rate and substituent groups was also studied. All the compounds synthesized were confirmed by ^1 H NMR, ^13C NMR and IR.

关 键 词：[(吲哚基)-甲基]丙二酸二甲酯 丙二酸二甲酯 硼酸 醛 无溶剂 

分 类 号：O625.3[理学—有机化学]