T2DM男性患者骨密度、IGF-I、IGF-II、维生素D的变化及相关性研究  

A study on the change and correlation of bone mineral density,vitamin D,IGF-I,IGF-II in T2DM male patients

作　　者：张燕 曾荣峰 李延兵[2] 

机构地区：[1]广东省连州市人民医院内科,513400 [2]中山大学附属第一医院内科,广州510080

出　　处：《白求恩医学杂志》2015年第3期230-231,共2页Journal of Bethune Medical Science

摘　　要：目的探讨2型糖尿病（T2DM）男性患者骨密度、胰岛素样生长因子I（IGF-I）、胰岛素样生长因子II（IGF-II）及维生素D的变化及相关性。方法选取T2DM男性患者100例（T2DM组）,同期选取健康体检男性50例（对照组）,分别检测两组腰椎体（L2-4）与股骨颈骨密度、IGF-I、IGF-II及血清25-羟维生素D3水平变化,分析其相关性。结果 T2DM组患者L2-4与股骨颈骨密度、IGF-I、IGF-II、25-羟维生素D3均低于对照组（P〈0.01）;L2-4骨密度、股骨颈骨密度、IGF-I、IGF-II、25-羟维生素D3间两两比较均呈正相关性（均P〈0.01）。结论 T2DM男性患者存在骨密度、IGF-I、IGF-II及维生素D水平降低,IGF-I、IGF-II、维生素D水平降低可能是引发T2DM男性患者骨密度降低的相关原因。Objective To investigate the type 2 diabetes mellitus（T2DM）and bone mineral density（BMD） in male patients with insulin-like growth factor I（IGF-I）,insulin-like growth factor II（IGF-II）,the change and correlation of vitamin D.Methods One hundred cases of T2DM patients were chosen as T2DM group,50 cases of healthy controls undergoing physical examinations during the same period were chosen as control group and lumbar vertebral body（L2-4 ）and femoral neck BMD,IGF-I,IGF-II and serum 25-hydroxy vitamin D3 were detected and correlation analysis was performed.Results In T2DM group,L2-4 and femoral neck BMD,IGF-I,IGF-II, 25-hydroxy vitamin D3 were lower than that of the control group（ P 〈0.01）.L2-4 bone mineral density and bone mineral density of fem-oral neck,IGF-I,IGF-II,25-hydroxy vitamin D3 between the two groups showed a positive correlation（ P 〈0.01）.Conclusion T2DM male patients may suffer from reduced bone mineral density,lower levels of IGF-I,IGF-II,vitamin D,and reduced IGF-I,IGF-II and vi-tamin D levels may be the relative factors causing decrease of BMD in T2DM male patients.

关 键 词：T2DM 男性 骨密度 IGF-I IGF-II 维生素D 

分 类 号：R587.1[医药卫生—内分泌]