从气血角度探讨纤维化肺脏微环境  

Discussion of the Microenviroment in the Lung Fibrosis from the Perspective of Qi and Blood

作　　者：李丽娜[1] 张冬梅[2] 李丽君[1] 吴谦[1] 陈萌[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029 [2]北京中医药大学东直门医院,北京100700

出　　处：《辽宁中医药大学学报》2015年第7期63-66,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81173192)

摘　　要：肺纤维化存在于多种肺部疾病中。虽然益气活血法作为治疗肺纤维化的治则已经被大多数临床研究者认同,但中医对于肺纤维化的病因病机认识仍不十分清楚。该文从中医角度分析了肺的功能与气血的关系,结合肺纤维化组织微环境的变化与中医气虚证、血瘀证生物学表现,提出纤维化状态下肺脏组织微环境的病理改变(局部免疫失衡、气体交换障碍和高凝状态)符合气虚血瘀证。益气活血药能够调节局部免疫失衡,降低血黏度,提高支气管肺泡干细胞存活关键基因c-kit的表达水平,改善局部微环境,有利于肺脏组织修复。Lung fibrosis appears in kinds of lung diseases. The treatment rule of boost Qi and activate blood huoxue has been supposed by most of clinic researchers. But it is not very clear about the cause and mechanism of lung fibrosis in Chinese medicine. We analyse the relationship between lung function and Qi and blood in Chinese medicine. Comparing the appearance of microenvironment in fibrotic lung and the appearance of Qi deficiency and blood stasis,we found that the changing of microenvironment in fibrotic lung（imbalanced immunities,obstruction of gas-exchang-ing,and blood stasis condition）consisted with the appearance of Qi deficiency and blood stasis. Huangqi and Danggui can adjust the imbalanced immunities,amend the blood stasis condition,and improve the expression of c-kit,which is obstruction to repair the lung tissue.

关 键 词：肺纤维化 气虚血瘀 微环境 气血 

分 类 号：R563.9[医药卫生—呼吸系统]