清血汤联合别嘌醇治疗肾性高尿酸血症的临床疗效观察  

Observation on clinical efficacy of Qingxuetang combined with allopurinol treating renal hyperuricemia

作　　者：焦剑[1] 车树强 赵亚[1] 王莹[1] 范军[1] 马丽[1] 

机构地区：[1]天津市中医药研究院附属医院,天津300120

出　　处：《天津中医药大学学报》2015年第3期140-143,共4页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：天津市中医药管理局课题(13030)

摘　　要：[目的]观察清血汤联合不同剂量别嘌醇治疗肾性高尿酸血症的疗效,探求在中药治疗基础上减少别嘌醇用量以减少别嘌醇不良反应。[方法]90例患者按随机数字表法随机分为3组,每组各30例,予清血汤分别联合别嘌醇常规量150 mg、中量100 mg、低量50 mg,观察第0、2、4、8周血肌酐(Scr)、血尿素氮(BUN)、肾小球滤过率(GFR)、血尿酸(UA)及症状积分。[结果]3组间总疗效差异无统计学意义(P>0.05)。3组间Scr、BUN、GFR及症状积分差异无统计学意义(P>0.05)。降UA清血汤联合别嘌醇低量不及常规量(P<0.05),中量与常规量差异无统计学意义(P>0.05)。清血汤联合别嘌醇中量的不良反应例数较常规量少,程度轻。[结论]降UA清血汤联合别嘌醇100 mg可以替代清血汤联合别嘌醇150 mg,安全有效。[Objective] Curative effect of Qingxuetang combined with different dose of allopurinol in treating renal hyperuricemia. Try to reduce the dose of allopurinol on the basis of traditional Chinese medicine for reducing allopurinol＇s adverse reactions. [Methods] Ninty patients were randomly divided into three groups, with 30 cases in each group. On basis of routine treatment and Qingxuetang treatment, each group was separately given 150 mg allopurinol, 100 mg allopurinol, 50 mg allopurinol. We observe the chang of Scr、BUN、GFR、UA and symptom score at 0、2、4、8 week. [Results] The total curative effect of three groups were no statistically significant difference（P〈0.05）. Scr, BUN, GFR and symptom score in each group was no statistically significant difference（P〉0.05）. In reducing UA aspect, Qingxuetang combined with allopurinol 100 mg was no statistically significant difference as allopurinol 150 mg（P〉0.05）. Qingxuetang combined with allopurinol 50 mg reducing UA was less than with allopurinol 150 mg（P〈0.05）. The cases of Qingxuetang combined with allopurinol 100 mg having adverse reactions were less than with allopurinol 150 mg,and degree of adverse reaction was lighter than with allopurinol 150 mg.[Conclusion] The three groups were no statistically significant differences in improvement of renal function and clinical symptoms in renal hyperuricemia. In reducing UA aspect, Qingxuetang combined with allopurinol 100 mg can replace Qingxuetang combined with allopurinol 150 mg. Qingxuetang combined with allopurinol 100 mg was better effective and security than with allopurinol 150 mg.

关 键 词：肾性高尿酸血症 清血汤 别嘌醇 

分 类 号：R692.6[医药卫生—泌尿科学]