自动化固相萃取法合成11C-乙酸盐的影响因素  

Influential factors of solid-phase extraction method to automate the synthesis of 11C-acetate

作　　者：赵雷[1] 杨雁[2] 孙华[1] 

机构地区：[1]云南省肿瘤医院PET/CT中心、昆明医科大学第三附属医院,650118 [2]昆明医科大学海源学院,650106

出　　处：《国际放射医学核医学杂志》2015年第3期224-227,234,共5页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的：探讨采用国产模块自动化固相萃取法合成11C-乙酸盐的影响因素。方法通过调节11C-乙酸盐合成过程中加速器靶内11CO2释放速度、捕获环释放11CO2时间、甲基溴化镁/四氢呋喃（CH3MgBr/THF）浓度及用量、氮气气流、气压及合成体系中水等参数，研究这些因素对11C-乙酸盐合成效率的影响，从而找到最优化的合成条件。结果经过18批次的条件优化实验后，11C-乙酸盐的合成效率为（53．7±3．6）%，放化纯度＆gt;99%。结论 CH3MgBr/THF浓度及用量和氮气气流、气压是影响11C-乙酸盐合成效率的主要因素。Objective To discuss the factors that affect the synthesis of 11C-acetate via a domestic automated solid-phase extraction method. Methods The synthesis efficiency of 11C-acetate was influenced by the release rate of 11CO2 from the cyclotron target, the release time of 11CO2 by the capture ring, the concentration and volume of tetrahydrofuran（THF） with CH3MgBr, nitrogen current rate and pressure, water in the synthesis system. Thus, these parameters were optimized. Results After performing 18 runs of the conditional parallel experiment, the synthesis efficiency of 11C-acetate was increased to （53.7±3.6）%, and the radiochemical purity was more than 99%. Conclusion The main factors that affect the efficiency of 11C-acetate synthesis were the concentration and volume of CH 3MgBr/THF, the current rate of nitrogen, and the pressure of nitrogen.

关 键 词：碳放射性同位素 乙酸盐类 固相萃取法 自动化合成 影响因素 

分 类 号：TQ421.7[化学工程]