JAK／STAT信号通路在肺纤维化中作用的研究进展  

JAK/STAT signaling pathway in pulmonary fibrosis

作　　者：卢森[1] 陈秋华[1] 黄英姿[1] 

机构地区：[1]东南大学附属中大医院重症医学科,南京210009

出　　处：《国际呼吸杂志》2015年第12期951-953,共3页International Journal of Respiration

基　　金：国家自然科学基金资助项目（81372093）;中华医学会科研专项基金（10030190241）

摘　　要：蛋白酪氨酸激酶（JAK）/信号转导转录激活因子（STAT）信号通路是介导炎症反应的重要信号通路之一，广泛参与细胞的增生、分化、凋亡、免疫调节等病理生理过程。JAK/STAT信号通路通过介导肺巨噬细胞、成纤维细胞、肺泡上皮细胞的病理性活化及损伤，对肺纤维化进程具有重要调控作用。此文就JAK/STAT信号通路在肺纤维化中的作用机制及研究进展作一综述。Janus kinase （JAK）/signal transducer and activator of transcription （STAT）signaling pathway,which has been shown to play an important role in the inflammatory response,involves in cell pathophysiological processes including cell proliferation,migration,survival,differentiation and so on. Recent researches have verified that JAK/STAT pathway could enhance the development of pulmonary fibrosis through mediating pathological activation and injury of cells such as macrophage cells,myo-fibroblast cells and alveolar epithelial cells.The effects of JAK/STAT pathway on the development and progression of pulmonary fibrosis are reviewed in this paper.

关 键 词：蛋白酪氨酸激酶 信号转导转录激活因子 炎症 肺纤维化 

分 类 号：R965.1[医药卫生—药理学]