卡前列素氨丁三醇注射液应用于宫缩乏力产后出血的临床分析  

Clinical analysis of Romethamine Injection used in uterine atony postpartum hemorrhage

作　　者：杨茵梅[1] 廖丹[1] 

机构地区：[1]广东省高州市人民医院药剂科,广东高州525200

出　　处：《中国医药导报》2015年第18期58-61,共4页China Medical Herald

基　　金：广东省茂名市医学类科技计划立项项目(2013260)

摘　　要：目的：分析卡前列素氨丁三醇注射液应用于宫缩乏力产后出血的预防效果，分析其临床应用价值。方法选取2010年5月～2014年5月广东省高州市人民医院收治的226例具有宫缩乏力产后出血风险的产妇，按照随机数字表分为观察组及对照组，每组各113例。对照组产妇均给予常规治疗，观察组在此基础上加用卡前列素氨丁三醇注射液治疗，比较两组产妇产后出血量、临床疗效及不良反应情况。结果观察组第三产程及产后2 h、24 h出血量均显著低于对照组（P〈0.05）；观察组产后出血、子宫切除率分别为14.2%、1.8%，显著低于对照组的29.2%、4.4%（P〈0.05）；观察组临床总有效率为92.9%，显著高于对照组的54.9%（P 〈0.05）；观察组与对照组不良反应发生率分别为21.2%、22.1%，差异无统计学意义（P跃0.05）。结论卡前列素氨丁三醇能够有效缩短产妇第三产程，减少产后出血时间及出血量，对于降低产妇产后出血及子宫切除风险具有重要意义，同时该药起效快、作用持续时间长、注射操作方便且安全性较高的优势亦显著提高了其临床应用价值。Objective To analyze the preventive effect of Romethamine Injection in uterine atony postpartum hemorrhage, and to analyze its clinical application value. Methods 226 cases female patients with the risk of uterine atony postpartum hemorrhage postpartum from May 2010 to May 2014 in the People＆#39;s Hospital of Gaozhou City were selected, they were divided into observation group and control group randomly, with 113 cases in each group. Puerperas of the control group were given conventional treatment, the observation group was given the treatment of Romethamine Injection based on the conventional treatment. The postpartum hemorrhage volume, clinical efficacy and adverse reaction of two groups were compared. Results The third stage of labor and bleeding volume of 2 h, 24 h after postpartum of the observation group were significantly lower than those of the control group （P 〈 0.05）; the rates of postpartum hemorrhage, hysterectomy in the observation group were 14.2%, 1.8%, which were significantly lower than the 29.2%, 4.4% of the control group （P〈 0.05）; the clinical total effective rate of the observation group was 92.9%, which was significantly higher than the 54.9% in the control group （P 〈 0.05）; the adverse reaction rates of the observation group and the control group were 21.2%, 22.1% respectively, which had no significant difference （P ＆gt;0.05）. Conclusion Romethamine Injection can effectively shorten the third stage of labor, reduce the postpartum bleeding time and bleeding volume. It has important significance in reducing the risk of uterine resection and postpartum bleeding. At the same time, advantages of the drug fast acting, long acting time, injection of convenient operation and high security also significantly improved its value of clinical application.

关 键 词：卡前列素氨丁三醇注射液 宫缩乏力 产后出血 

分 类 号：R714.461[医药卫生—妇产科学]