银杏叶片联合阿托伐他汀治疗冠心病心绞痛的临床疗效研究  

Clinical efficacy of Ginkgo biloba extract combined with atorvastatinin in the treatment of coronary heart disease angina

作　　者：蒋欣[1] 潘玉艳[2] 贺亚玲[3] 金慧瑾 吴伟[3] 

机构地区：[1]南京农业大学医院药剂科,江苏省南京市210000 [2]常州市第二人民医院药剂科 [3]南京农业大学医院办公室

出　　处：《临床合理用药杂志》2015年第15期1-3,共3页Chinese Journal of Clinical Rational Drug Use

基　　金：中央高校基本科研业务费专项资金资助项目;银杏叶制剂的不良反应探究(KYYL201205)

摘　　要：目的探讨银杏叶片联合阿托伐他汀治疗冠心病心绞痛的临床疗效。方法选择2012年7月—2013年7月于南京农业大学医院及常州市第二人民医院接受治疗的冠心病心绞痛患者82例,随机分为治疗组和对照组,各41例。两组患者均给予常规治疗,对照组在常规治疗基础上给予阿托伐他汀治疗,治疗组在常规治疗基础上给予银杏叶片联合阿托伐他汀治疗。比较两组患者的临床疗效及心电图疗效,治疗前及治疗后1个月、3个月和6个月血脂水平〔总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDLC)〕;治疗6个月后随访心脑血管事件发生情况。结果观察组临床治疗总有效率、心电图治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后治疗组TC、TG和LDL-C水平低于对照组,差异有统计学意义(P<0.05)。对两组患者进行为期6个月的随访,对照组患者心绞痛、心肌梗死及心力衰竭的发生率高于治疗组,差异有统计学意义(P<0.05)。结论银杏叶片联合阿托伐他汀能有效改善患者心绞痛症状,降低患者血脂水平,减少患者脑血管疾病的发生。Objective To study the clinical efficacy of Ginkgo biloba extract combined with atorvastatin in the treat-ment of coronary heart disease angina. Methods In Nanjing Agricultural University Hospital and the Second People＆#39;s Hospital of Changzhou from July 2012 to July 2013,a total of 82 coronary heart disease angina patients were selected and randomly divid-ed into control group and treatment group,41 cases in each group. All patients were given conventional therapy,control group were treated with atorvastatin on the basis of conventional therapy,treatment group were treated with Ginkgo biloba extract com-bined with atorvastatin on the basis of conventional therapy,clinical efficacy and electrocardiograph（ ECG）efficacy,before and 1 month,3 months and 6 months after treatment serum lipid level〔total cholesterol（ TC）,triacylalycerol（ TG）,low density lipoprotein cholesterin（ LDL-C） and high density lipoprotein cholesterin（ HDL-C）〕,followed up 6 months for the observa-tion of cardiocerebral vascular events of the two groups were compared. Results The total effective rates of clinical and ECG of treatment group were higher than control group after treatment,the differences were statistically significant（P〈0. 05）. The TC,TG and LDL-C levels of treatment group were lower than control group after treatment,the differences were statistically significant（P〈0. 05）. Followed up 6 months,the occurrence rate of angina,myocardial infarction and heart failure of control group were higher than treatment group,the differences were statistically significant（P〈0. 05）. Conclusion Ginkgo biloba extract combined with atorvastatin can effectively relieve angina,decrease the level of blood lipid and reduce the incidence of ca-diocerebral vascular diseases.

关 键 词：冠心病 心绞痛 银杏叶片 阿托伐他汀 治疗结果 

分 类 号：R541.4[医药卫生—心血管疾病]