硫辛酸对烧伤兔应激期保护作用研究  

Protective effect of thioctic acid in burned rabbit stress period

作　　者：史英钦[1] 高丽丽[1] 王朝卿[1] 吴慧珍[1] 

机构地区：[1]河北省人民医院药学部,河北省石家庄市050051

出　　处：《临床合理用药杂志》2015年第15期88-89,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨硫辛酸对烧伤兔应激期保护作用。方法选取新西兰大耳白兔20只,随机分为1组与2组,各10只。1组烧伤后不予以药物治疗,2组烧伤后予以硫辛酸治疗。观察两组烧伤前1d、烧伤后第1、3、5、7天血浆内毒素水平、细菌检测结果及烧伤前1d,烧伤后第3、5天血浆丙二醛(MDA)水平。结果烧伤前1d、烧伤后第1、7天两组血浆内毒素水平比较,差异无统计学意义(P>0.05),烧伤后第3、5天2组血浆内毒素水平低于1组,差异有统计学意义(P<0.05);烧伤前1d两组血浆MDA水平比较,差异无统计学意义(P>0.05),烧伤后第3、5天2组血浆MDA水平低于1组,差异有统计学意义(P<0.05);烧伤前1d、烧伤后第1、7天两组细菌检测阳性率比较,差异无统计学意义(P>0.05),烧伤后第3、5天2组细菌检测阳性率低于1组,差异有统计学意义(P<0.05)。结论硫辛酸治疗烧伤兔应激期的疗效显著,能有效控制氧自由基产生,减少脂质过氧化,降低血浆内毒素水平及器官组织损伤。Objective To study the protective effect of thioctic acid in burned rabbit stress period. Methods A to-tal of 20 New Zealand big-ear white rabbits were selected and randomly divided into A group and B group,each of 10 rabbits. A group did not receive any drug treatment after burn,B group received thioctic acid after burn. Plasma endotoxin level and bacteria test results 1 day before burn,on the first,third,fifth,seventh day of burn,plasma malondialdehyde（ MDA） level 1 day before burn,on the third,fifth day of burn were compared between the two groups. Results No statistically significant differences of plasma endotoxin level or bacteria positive detection rate 1 day before burn,on the seventh day of burn was found between the two groups（P〉0. 05）;plasma endotoxin level and bacteria positive detection rate on the third,fifth day of burn of B group were statistically significantly lower than those of A group,respectively（P＆lt;0. 05）. No statistically significant differ-ences of plasma MDA level 1 day before burn was found between the two groups（ P〉0. 05）;plasma MDA level on the third, fifth day of burn of B group was statistically significantly lower than those of A group,respectively（P＆lt;0. 05）. Conclusion Thioctic acid has a notable curative effect on burned rabbit stress period,can effectively control the production of oxygen free radical,reduce lipid peroxidation,plasma endotoxin level and organ damage.

关 键 词：烧伤 硫辛酸 兔 内毒素类 

分 类 号：R644[医药卫生—外科学]