对甲氧基苯基-2,3,4,6-四-O-乙酰基-α-D-吡喃甘露糖苷的合成  

Synthesis of p-Methoxyphenyl 2,3,4,6-tetra-O-acetyl-α-D-Mannopyranoside

作　　者：陈朗秋[1] 伍桂龙[1] 谢蓉[1] 

机构地区：[1]湘潭大学化学学院环境友好化学与应用省部共建教育部重点实验室,湖南湘潭411105

出　　处：《徐州工程学院学报（自然科学版）》2015年第2期24-27,共4页Journal of Xuzhou Institute of Technology(Natural Sciences Edition)

基　　金：湖南省自然科学基金(14JJ2067;10JJ6023)

摘　　要：对甲氧基苯基-2,3,4,6-四-O-乙酰基-α-D-吡喃甘露糖苷是重要的有机合成中间体.以D-甘露糖为原料,经乙酰化、选择性脱C1位乙酰基、转化成三氯乙酰亚胺酯、与受体酚偶联和脱保护4步反应立体专一性地合成了对甲氧基苯基-2,3,4,6-四-O-乙酰基-α-D-吡喃甘露糖苷,目标化合物的结构经氢谱和质谱分析得到了确证,方法有效、产率高.p‐Methoxyphenyl 2 ,3 ,4 ,6‐tetra‐O‐acetyl‐α‐D‐Mannopyranoside is an important intermediate for organic synthesis .p‐Methoxyphenyl 2 ,3 ,4 ,6‐tetra‐O‐acetyl‐α‐D‐Mannopyranoside was stereospecifical‐ly synthesized through five consecutive steps including acetylation ,selective deacetylation at the C1 posi‐tion ,conversion to trichloroacetimidate and coupling with acceptors phenol .The structure of the target compound was confirmed by the 1H NMR and MS analysis which showed that the method was effective and practical ,and the yield was high .

关 键 词：对甲氧基苯基-2 3 4 6-四-O-乙酰基-α-D-吡喃甘露糖苷 D-甘露糖 对甲氧基苯酚 

分 类 号：O629.13[理学—有机化学]