尼古丁羟丙基-β-环糊精包合物的制备及稳定性考察  

Study on preparation and stability of nicotine-HP-β-cyclo dextrin inclusion complex

作　　者：郑欣[1] 刘新[1] 欧阳雪[1] 李美燕[1] 

机构地区：[1]重庆医科大学药学院,重庆400016

出　　处：《中国医院药学杂志》2015年第12期1138-1142,共5页Chinese Journal of Hospital Pharmacy

摘　　要：目的:制备尼古丁羟丙基-β-环糊精(HP-β-CD)包合物,并进行包合物的稳定性考察。方法:采用冷冻干燥法制备尼古丁的包合物,通过星点设计-效应面法优化制备工艺,并做了热稳定性初步考察。结果:最佳的包合工艺为HP-β-CD与尼古丁物料摩尔比为3.36∶1,包合温度45℃,包合时间3.5 h,水与HP-β-CD摩尔比为20∶1,平均包合率为56.22%,与预测值吻合。尼古丁采用环糊精包合后稳定性有显著提升。结论:该模型预测下的优化工艺可行,可作为尼古丁包合物的制备工艺。OBJECTIVE To prepare inclusion complex of nicotine with HP-β-CD（ nit-HP-β-CD）,and study stability of inclusion complex. METHODS nit-HP-β-CD was prepared by freeze-drying method. Central composite design and response surface methodology were chosen to optimize process of preparation. Thermal stability was also primarily studied. RESULTS Optimum technological parameters were as follows： ratio of HP-β-CD / nit 3. 36∶ 1,reaction temperature was 45 ℃,ratio of water / HP-β-CD 20∶ 1,and reaction time was 3. 5 h. Inclusion rate was 56. 22%,which was close to predicted value. Nicotine had significantly improved stability after included by HP-β-CD. CONCLUSION Optimized process predicted in this model is feasible,and can be used as preparation process of nicotine.

关 键 词：尼古丁 羟丙基-Β-环糊精 包合物 效应面法 稳定性 

分 类 号：R943[医药卫生—药剂学]