雷丸及吡喹酮对猬裂头蚴感染小鼠的疗效观察  

Efficacy of Omphalia lapidescens and praziquantel for treatment of mice infected with pleroceroids

作　　者：李金福[1] 陈艳[1] 徐婧[1] 

机构地区：[1]贵阳医学院人体寄生虫学教研室,贵州贵阳550004

出　　处：《现代预防医学》2015年第13期2409-2411,共3页Modern Preventive Medicine

基　　金：贵州省科技厅基金项目支助[黔科合J字(2012)2042号]

摘　　要：目的了解雷丸及吡喹酮对猬裂头蚴疗效的影响。方法 (1)从黑斑蛙体内检获裂头蚴。将112只昆明小鼠分成14组(A-I),每只小鼠经口感染裂头蚴5条,每组8只小鼠,每组共感染裂头蚴40条。(2)感染后1周,A-C组小鼠分别用吡喹酮灌胃治疗1个疗程(1次/d×3 d),吡喹酮1个疗程的总剂量分别为1 500 mg/kg、3 000mg/kg和6 000 mg/kg;D-F组分别用雷丸灌胃治疗1个疗程(1次/d×3 d),雷丸1个疗程的总剂量分别为1 200mg/kg、2 400 mg/kg和4 800 mg/kg。(3)H-J组和K-M组小鼠分用吡喹酮和雷丸治疗一个疗程后,间隔7 d,再治疗1个疗程,H-J组的总剂量同A-C组,K-M组的总剂量同D-F组;G组和N组小鼠仅灌服生理盐水,分别作为A-F组和H-M组小鼠的对照组。所有处理组及对照组在疗程结束后1周剖杀,分别计数每组小鼠的裂头蚴检获数及减虫率。结果 (1)1个疗程治疗:A组及B组小鼠与G对照组相比,裂头蚴的减虫率差异无统计学意义(P>0.05);C组小鼠裂头蚴的平均检获数为2.13条,裂头蚴的减虫率为41.32%,与G对照组相比,差异有统计学意义(P<0.05);D组、E组及F组小鼠裂头蚴的减虫率分别为48.21%、51.79%和44.90%,与G对照组相比,差异均有统计学意义(P<0.05)。(2)2个疗程的治疗:H、I和J组与N对照组相比,裂头蚴的减虫率差异无统计学意义(P>0.05);K、L和M组小鼠裂头蚴的减虫率分别为48.22%、55.62%和59.17%,与N对照组相比,差异均有统计学意义(P<0.05),雷丸各治疗组之间裂头蚴的减虫率差异无统计学意义(P>0.05)。结论雷丸和吡喹酮在体内对猬裂头蚴感染小鼠有一定的治疗作用,雷丸的疗效优于吡喹酮。Objective To observe the efficacy of Omphalia lapidescens and praziquantel for the treatment of mice infected with Spirometra erinacei pleroceroids. Methods The pleroceroids were taken from frogs（Rana nigromaculata）. A total of 112 mice were equally divided into 14 groups（A-I, 8 mice in each group）, and each mouse was orally infected with 5 plerocercoids. One week after infection, groups A-C were treated with a 3-day course of praziquantel（total dosage： 1500, 3000, and 6000 mg/kg, 1 time daily for3 days）; groups D-F were treated by different dosages of Omphalia lapidescens（total dosage： 1200, 2400, and 4800 mg/kg, 1 time daily for 3 days）; groups H-J, and K-M were treated with the second course of praziquantel and Omphalia lapidescens with the same total dosage at 1week interval after the first course; groups G and N were used as control for A-F and H-M respectively. One week later, the mice were killed, the number of pleroceroids was recorded and worm detection rate was determined. Results One course of treatment： The number of worms recovered from A or B group mice had no significant differences with that of the G control group（P〈0.05）. The reduction rate of pleroceroids from C group was 41.32%, compared with the G control group. The difference had a statistical significance（P〈0.05）. The reduction rates of pleroceroids from D, E, and F group mice were 48.21%, 51.79%, and44.90% respectively, compared with the control group. The difference had a statistical significance（P〈0.05）; Two courses of treatment： The number of worms recovered from H, I, or J group mice had no significant difference with that of the N control group（P〈0.05）; The reduction rates of pleroceroids from K, L, or M groups were 48.22%, 55.62% and 59.17% respectively, compared with the H control group, the difference had statistical significance（P〈0.05）; The reduction rate of pleroceroids among Omphalia lapidescens groups had no significant difference（P〉0.05）. Conclusion Omphalia lapidesce

关 键 词：雷丸 吡喹酮 裂头蚴 疗效 

分 类 号：R117[医药卫生—公共卫生与预防医学]