代谢综合征及其组分与老年血尿酸水平的关系  

Correlation Between Serum Uric Acid Levels in the Elderly and Metabolic Syndrome and Its Components

作　　者：高素颖 颜应琳 于凯 王拥军 赵永娜 李芳 张广波 刘东亮 何艳 杨红娜 

机构地区：[1]任丘康济医院神经科,河北省任丘市062550

出　　处：《中国全科医学》2015年第17期1995-2000,共6页Chinese General Practice

基　　金：河北省科技支撑计划项目(12276104D-90)

摘　　要：目的：探讨代谢综合征（MS）及其组分与老年血尿酸（SUA）水平的关系。方法采用整群随机抽样法选取任丘市年龄60～70岁的常住居民5010例为研究对象，进行面对面健康问卷调查、体格检查、实验室检查。依据2007年中国成人血脂异常防治指南中确定的MS诊断标准对研究对象进行诊断，并按照SUA水平进行四分位分组，探讨MS与SUA的关系。结果随着SUA水平的增加，男性所占比例逐渐增高，女性所占比例逐渐降低，MS、脑卒中或短暂性脑缺血发作（ TIA）、吸烟、过量饮酒、缺乏体力活动、抗血小板药物使用率逐渐增高，被动吸烟率逐渐降低，腰围、体质指数（BMI）、收缩压、舒张压、空腹血糖（FPG）、三酰甘油（TG）、胰岛素抵抗指数（HOMA-IR）逐渐增高，总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）水平逐渐降低，差异均有统计学意义（P＜0.05）。男性血尿酸水平第1～4分位者 MS 患病率分别为15.77％、19.59％、23.98％和37.89％，女性分别为29.83％、32.58％、41.63％和59.47％。随着SUA水平的增加，男、女性MS患病率均呈增加趋势（ P＜0.05）。在调整了性别、年龄及MS其他组分后，Logistic回归分析结果显示，SUA水平是男性中心性肥胖、高TG血症的独立危险因素（ P＜0.01），是女性中心性肥胖、高血压、高TG血症、低HDL-C血症的独立危险因素（ P＜0.01）；与第1分位比较，男女性第3、4分位发生MS的危险增加（P＜0.01）。随着MS组分的增加，男女性SUA水平逐渐升高，HUA患病率亦逐渐升高（P＜0.01）。结论 MS各组分与SUA水平密切相关，SUA水平是MS的重要组成部分，提示在MS预防和控制过程中，可将SUA水平作为MS预测及早期防治的一项指标。Objective To investigate the relationship between metabolic syndrome（ MS） and brachial-ankle pulse wave velocity（ baPWV）. Methods A total of 692 patients who were admitted into the Cardiovascular Research Center of Union Hospital of Huazhong University of Science and Technology from October 2010 to October 2013 were enrolled. We determined a series of basic MS syndromes,including overweight or obesity,excessive waistline（ male≥90 cm;female≥80 cm）,abnormal glucose tolerance or diabetes mellitus,hypertension. According to different components,272 subjects with only basic MS syndromes were assigned into the MS1 group,270 subjects with both basic MS syndromes and abnormal TG were assigned into the MS2 group,and 150 subjects with both basic MS syndromes and abnormal HDL-C were assigned into MS3 group. Another 300 health subjects were enrolled as the control group. The venous blood of the subjects was sampled,and then tests were conducted on TC,TG,LDL-C,HDL-C,FPG,2 hPG and hs-CRP. The baPWV of the subjects was also measured. Results The four groups were significantly different（P〈0. 05）in age,body weight,BMI,waistline,SBP,DBP,PP,MAP,TC,TG, LDL-C,HDL-C,FPG,2 hPG, hs-CRP and baPWV;MS1 group, MS2 group, MS3 group were higher （ P 〈0. 05 ） than the control group in age,body weight,BMI,waistline,SBP,DBP,PP,MAP,FPG,2 hPG,hs-CRP and baPWV;MS2 group and MS3 group were higher（P〈0. 05）than MS1 group in body weight,BMI,waistline,SBP,DBP,PP,MAP, FPG,2 hPG and baPWV;MS3 group was higher （ P 〈0. 05 ） than MS2 group in the waistline of males, SBP, PP, TC, LDL-C and baPWV. The rectilinear correlation analyses showed that age,BMI,SBP,PP,MAP,TG,FPG,2 hPG were positively correlated with baPWV,and DBP and HDL-C were negatively correlated（P〈0. 05）with baPWV. The multivariate linear regression correlation analyses showed gender,age,BMI,SBP,DBP,2 hPG and TG were influencing factors for baPWV of MS patients（ P〈0. 05 ）. Conclusion More abnormal MS components are associated with severer arterios

关 键 词：代谢综合征X 尿酸 高尿酸血症 老年人 

分 类 号：R587.1[医药卫生—内分泌]