机构地区:[1]上海交通大学医学院附属同仁医院肾脏科,上海市200336
出 处:《中国全科医学》2015年第18期2152-2157,共6页Chinese General Practice
摘 要:目的:了解慢性肾脏病(CKD)住院患者的患病情况及其影响因素,为社区医院提供依据,及早筛查具有 CKD 高危因素的居民,及早干预或转诊。方法2010年1月—2013年7月上海交通大学医学院附属同仁医院肾脏科住院患者(≥18岁)2079例,其中 CKD 患者1497例(72.01%),记录患者的性别、年龄、血生化{肌酐、尿素氮、尿酸、血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、清蛋白、空腹血糖、糖化血红蛋白(HbA1c )、钙、磷、碱性磷酸酶(AKP)、甲状旁腺素(PTH)、25羟维生素D3〔25(OH)D3〕水平等}、尿常规、尿微量蛋白(MAU)、24 h 尿蛋白定量、肾脏 B 超及高血压病史、糖尿病病史、全身麻醉手术史、脑血管疾病史等,并记录其入院当日血压值。结果 CKD 患者原发病分别为慢性肾炎496例,糖尿病肾病377例,高血压性肾硬化366例,其他258例。女性患者平均年龄大于男性〔(71.8±15.0)岁与(67.0±16.5)岁〕(t =-5.848,P <0.05)。男性患者 MAU 高于女性,24 h 尿蛋白定量多于女性,肾小球滤过率估计值( eGFR)低于女性(P <0.05)。非老年组(<65岁)MAU、24 h 尿蛋白定量、eGFR 高于老年组(≥65岁)(P <0.05)。CKD 1~5期患者空腹血糖、25(OH)D3水平比较,差异无统计学意义(P >0.05);患者年龄、肌酐、尿素氮、尿酸、血红蛋白、总胆固醇、三酰甘油、LDL、HDL、清蛋白、HbA1c、钙、磷、AKP、PTH、MAU、24 h 尿蛋白定量比较,差异均有统计学意义(P <0.05)。Pearson 相关分析显示,CKD 患者血肌酐与血红蛋白、总胆固醇、三酰甘油、LDL、清蛋白、钙呈负相关(P <0.05);与尿素氮、尿酸、磷、PTH、MAU、24 h 尿蛋白定量呈正相关( P <0.05)。二分类 Logistic 回归分析结果显示,肾囊肿、糖尿病病史、高血压病史、HbObjective To investigate the prevalence and risk factors of hospitalized adult patients of chronic kidney disease(CKD)in nephrology department,in order to provide informations for the community hospital. Methods Among 2 079 patients(age ≥ 18 years)who were admitted to Department of Nephrology,Tongren Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2010 to July 2013,1 497 cases(72. 01% )had CKD. The gender,age,blood biochemical indicators〔 creatinine,urea nitrogen,uric acid,hemoglobin,total cholesterol,triacylglycerol,LDL,HDL, albumin,fasting blood glucose,HbA1c ,calcium( Ca),phosphorus( P),AKP、PTH,25(OH)D3 〕,routine urine test results,MAU,24 - hour urinary protein excretion,renal ultrasonography results,history of hypertension,history of diabetes, history of interventional therapy, history of cardiovascular and cerebrovascular diseases, and the blood pressure were analyzed. Results The cause of CKD patients were chronic nephritis( 496 cases),diabetic nephropathy( 377 cases), hypertensive nephropathy(366 cases),and other diseases(258 cases). The female(71. 8 ± 15. 0 years old)was significantly older than the male(67. 0 ± 16. 5 years old)(t = - 5. 848,P 0. 05). There were significant difference in age,levels of creatinine,urea nitrogen,uric acid,hemoglobin,total cholesterol, triacylglycerol,LDL,HDL,albumin,HbA1c ,Ca,P,AKP,PTH,MAU and 24 - hour urinary protein amount among patients of CKD 1 - 5( P 〈 0. 05). Pearson correlation analysis results showed that serum creatinine level was correlated negatively with serum levels of hemoglobin,total cholesterol,triacylglycerol,LDL,albumin and Ca(P 〈 0. 05),while serum creatinine level was correlated positively with serum levels of urea nitrogen,uric acid,phosphorus and PTH,MAU,24 - hour urinary protein amount(P 〈 0. 05). According to binary Logistic regression analysis results,the decreased renal function had regressive relationship with renal cyst,hist
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