新型聚合物胶束及其在肿瘤治疗中的应用  

New Polymer Micelles and Its Application in Cancer Therapy

作　　者：杨舒迪 张学农[1] 

机构地区：[1]苏州大学药学院,苏州215123

出　　处：《中国药学杂志》2015年第12期1006-1011,共6页Chinese Pharmaceutical Journal

摘　　要：当前肿瘤化疗药物普遍存在低效高毒的缺点,选择合适的新剂型治疗肿瘤已成为重要的任务之一。本文利用肿瘤细胞内部的微环境特点,制备多种新型智能化聚合物胶束,可实现有效控制药物释放,毒副作用小,体内外疗效好的特点,具有很好的发展和应用前景。笔者以国内外研究文献为基础,简述聚合物胶束的构成、特点及主要制备方法,分类介绍了多种刺激响应性聚合物胶束,以及多种靶向聚合物胶束用作抗癌药物载体。The current prevalence of cancer chemotherapy drugs is inefficient and highly toxic,thus selecting the appropriate new forms of cancer treatment has become one of the important tasks. On the basis of domestic and foreign research literature,cutline the composition,characteristics and main preparation methods of polymeric micelles. Introduced varieties of stimuli-responsive polymer micelles,as well as targeted polymeric micelles used as an anticancer drug carrier. By making use of inside microenvironment of tumor cells,the preparation of various of new intelligent polymeric micelles with slight side effects and good treatment in virto and in vivo,can achieve effective control of drug release,which has great development and prospect in application.

关 键 词：聚合物胶束 响应性 载体 抗肿瘤 靶向 

分 类 号：R944[医药卫生—药剂学]