血清IL-16、IFN-r在慢性阻塞性肺疾病患者中的检测价值  

Clinical value of interleukin- 16,IFN- r detected in patient with chronic obstructive pulmonary disease

作　　者：李敬萍[1] 凌敏[1] 

机构地区：[1]新疆维吾尔自治区人民医院呼吸与危重症医学二科,新疆乌鲁木齐830002

出　　处：《吉林医学》2015年第13期2736-2738,共3页Jilin Medical Journal

摘　　要：目的:探讨慢性阻塞性肺疾病(COPD)患者血清及痰中白介素-16、IFN-r水平相关性及临床意义。方法:采用酶联免疫吸附试验(ELISA)检测COPD急性加重期、稳定期及健康对照组血清及痰中IL-16、IFN-r水平。结果:血清及痰液中COPD急性加重期患者IL-16、IFN-r水平均明显高于稳定期及健康对照组,且稳定期血清IL-16水平明显高于健康对照组,差异具有统计学意义((P<0.05)。在血清和痰液中IL-16与IFN-r水平呈正相关性(r=0.630、0.594,P<0.01)。结论:在COPD气道炎症中,IL-16、IFN-r共同参与了炎症发病过程,二者联合检测对COPD患者病情程度判断有一定意义。Objective Ti investigate the clinical significance and cirrelatiin between the serum if patients with chrinic ibstructive pul-minary disease（COPD）interleukin -16,IFN - r. Method Using enzyme - linked immunisirbent assay ti detect acute aggravating periid if COPD,stability and healthy cintrils in serum and sputum IL -16、IFN - r. Results In serum and sputum COPD patients with acute aggra-vating periid if IL - 16,IFN - r levels were significantly higher than that if stability and the healthy cintrils,and the level if serum IL -16 in stability significantly was higher than healthy cintrils. In serum and sputum there was a pisitively cirrelatiin with IFN - r and IL -16 level（r =0. 630、0. 594,p ﹤0. 01）. Conclusion IL - 16、IFN - r are invilved in the pathigenesis if COPD airway inflammatiin pricess,and have a certain significance if jiinting detectiin judgment in the severity if COPD patients.

关 键 词：慢性阻塞性肺疾病 IL-16 IL -16 INF-r 

分 类 号：R563.9[医药卫生—呼吸系统]