Comprehensive Alcohol-/Ion-Responsive Properties of Poly(N-Isopropylacrylamide-co-Benzo-18-Crown-6-Acrylamide) Copolymers  

聚(N-异丙基丙烯酰胺-共-苯并-18-冠-6丙烯酰胺)共聚高分子的醇和离子综合响应性能(英文)

作　　者：巨晓洁 皮硕伟 谢锐 郭晓静 柳杰译 余亚兰 江潞 陆小华 陈谦明 褚良银 

机构地区：[1]School of Chemical Engineering,Sichuan University [2]State Key Laboratory of Materials-Oriented Chemical Engineering,College of Chemistry and Chemical Engineering,Nanjing University of Technology [3]State Key Laboratory of Oral Diseases,Sichuan University

出　　处：《Chinese Journal of Chemical Engineering》2014年第9期1038-1045,共8页中国化学工程学报（英文版）

基　　金：Supported by the National Natural Science Foundation of China(21136006);the Foundation for the Author of National Excellent Doctoral Dissertation of PR China(201163);the National High Technology Research and Development Program(2012AA021403)

摘　　要：In this paper, we report on the comprehensive alcohol-/ion-responsive properties of a smart copolymer poly（N- isopropylacry]amide-co-benzo-18-crown-6-acrylamide） （P（NIPAM-co-BCAm））. The orthogonal design method is adopted for experimental design. The experimental results show that alcohol can trigger the shrinking and Ba2t can induce the swelling of the P（NIPAM-co-BCAm） copolymer. According to the phase transition tempera- ture （LCST） change results of the copolymer, the influence of variables on the LCST changes weakens in the following order： alcohol concentration 〉 alcohol species 〉 metal ion species 〉 BCAm concentration 〉 ion concentration. The larger the alcohol concentration and the larger the molecular size of alcohols, the lower the LCST value; on the contrary, the more the BCAm content in the copolymer or the larger the BCAm/ion complex stability constant （IgK） or the larger the ion concentration is, the higher the LCST value. For a P（NIPAM-co-BCAm ） copolymer with a fixed BCAm content, a binary function of ion concentration and IgK of BCAm/ion is developed to precisely predict the LCST values of the copolymer in different metal ion solutions. The results provide valuable information for fabricating artificial biomimetic G-protein-gated inwardly rectifying potassium （GIRK） channels that are activated by alcohol and inhibited by Ba2＋.In this paper, we report on the comprehensive alcohol-/ion-responsive properties of a smart copolymer poly(Nisopropylacrylamide-co-benzo-18-crown-6-acrylamide)(P(NIPAM-co-BCAm)). The orthogonal design method is adopted for experimental design. The experimental results show that alcohol can trigger the shrinking and Ba2+can induce the swelling of the P(NIPAM-co-BCAm) copolymer. According to the phase transition temperature(LCST) change results of the copolymer, the influence of variables on the LCST changes weakens in the following order: alcohol concentration N alcohol species N metal ion species N BCAm concentration N ion concentration. The larger the alcohol concentration and the larger the molecular size of alcohols, the lower the LCST value; on the contrary, the more the BCAm content in the copolymer or the larger the BCAm/ion complex stability constant(lgK) or the larger the ion concentration is, the higher the LCST value. For a P(NIPAM-co-BCAm)copolymer with a fixed BCAm content, a binary function of ion concentration and lgK of BCAm/ion is developed to precisely predict the LCST values of the copolymer in different metal ion solutions. The results provide valuable information for fabricating artificial biomimetic G-protein-gated inwardly rectifying potassium(GIRK) channels that are activated by alcohol and inhibited by Ba^(2+).

关 键 词：Stimuli-responsive materialPhase transition behaviorAlcohol-responsive propertyIon-responsive property 

分 类 号：O631.1[理学—高分子化学]