灰关联聚类法评价几种促透剂对延胡索乙素的促渗效果  

Effect of several penetration enhancers on transdermal absorption of tetrahydropalmatine with the gray relational clustering method

作　　者：叶星辰[1] 陈燕忠[1] 王晖[2] 

机构地区：[1]广东药学院药物研究所,广东广州510006 [2]广东药学院中药学院,广东广州510006

出　　处：《广东药学院学报》2015年第3期305-309,共5页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的探讨灰关联聚类法在几种促透剂的促渗效果综合评价中的运用。方法以延胡索乙素为模型药物,研究氮酮、薄荷醇、丁香油、广藿香油等促透剂对药物在离体大鼠背部皮肤上的透皮行为的影响,计算渗透系数、稳态流量、滞后时间、增渗倍数等透皮吸收参数,运用灰关联聚类法对促透效果进行综合评价。结果对延胡索乙素的促渗作用,几种促透剂的优劣顺序为:1%(以下均为质量分数)氮酮>1%丁香>1%薄荷醇+1%广藿香>1%氮酮+1%薄荷醇>1%氮酮+1%丁香>1%薄荷醇+1%丁香>1%薄荷醇>1%氮酮+1%广藿香>1%广藿香>1%丁香+1%广藿香;其中最优的是1%氮酮,关联度为0.9460,最差的是1%丁香+1%广藿香,关联度为0.455 0。结论灰关联聚类法对促透剂促透效果进行综合评价是可行的,可作为促透剂促透作用的综合评价方法。Objective To study the gray relational clustering method in three kinds of traditional Chinese medicine effective components on the promoting effect. Methods Tetrahydropalmatine was used as model drug. The research of the effect of penetration enhancers such as azone,menthol,clove oil,patchouli oil on transdermal absorption of tetrahydropalmatine in rats was done. The permeability coefficient,the steady-state flow,the lag time and the enhancing rate was calculated,and the gray relational clustering method was used to make a comprehensive evaluation of promoting effect. Results The promoting effect for tetrahydropalmatine was as follows： 1% azone 〉 1% clove 〉 1% menthol ＋ 1% patchouli 〉 1% azone ＋1% menthol 〉 1% azone ＋ 1% cloves 〉 1% menthol ＋ 1% clove 〉 1% menthol 〉 1% azone ＋ 1% patchouli〉 1% patchouli 〉 1% clove ＋ 1% patchouli. The best promoting effect was 1% Azone whose correlation degree was 0. 946 0 and the worst was 1% clove ＋ 1% patchouli whose correlation degree was 0. 455 0.Conclusion The gray relational clustering method is feasible to evaluate the transdermal effect of penetration enhancers and may become an approach to evaluate the effect of the transdermal absorption on drug synthetically.

关 键 词：薄荷醇 丁香油 广藿香油 促透剂 灰关联聚类法 

分 类 号：R285.5[医药卫生—中药学]