ANIMAL BEHAVIORAL MODELS OF TINNITUS  

作　　者：ZHANG Chao WANG Qiuju SUN Wei 

机构地区：[1]Department of Otolaryngology,Chinese PLA General Hospital [2]Center for Hearing & Deafness,Department of Communicative Dis-orders and Sciences,State University of New York at Buffalo 3435 Main Street,Buffalo,NY 14214

出　　处：《Journal of Otology》2014年第2期58-63,共6页中华耳科学杂志（英文版）

基　　金：supported by the grants of the National Key Basic Research Program of China,No.2014CB943001;the National Natural Science Foundation of China,Major Project,No.81120108009

摘　　要：The pathophysiology of tinnitus is poorly understood and treatments are often unsuccessful. A number of animal models have been developed in order to gain a better understanding of tinnitus. A great deal has been learned from these models re- garding the electrophysiological and neuroanatomical correlates of tinnitus following exposure to noise or ototoxic drugs. Re- liable behavioral data is important for determining whether such electrophysiological or neuroanatomical changes are indeed related to tinnitus. Of the many documented tinnitus animal behavioral paradigms, the acoustic startle reflex had been pro- posed as a simple method to identify the presence or absence of tinnitus. Several behavioral models based on conditioned re- sponse suppression paradigms have also been developed. In addition to determining the presence or absence of tinnitus, some of the behavioral paradigms have provided signs of the onset, frequency, and intensity of tinnitus in animals. Although none of these behavioral models have been proved to be a perfect model, these studies provide useful information on understanding the neural mechanisms underlying tinnitus.The pathophysiology of tinnitus is poorly understood and treatments are often unsuccessful. A number of animal models have been developed in order to gain a better understanding of tinnitus. A great deal has been learned from these models re- garding the electrophysiological and neuroanatomical correlates of tinnitus following exposure to noise or ototoxic drugs. Re- liable behavioral data is important for determining whether such electrophysiological or neuroanatomical changes are indeed related to tinnitus. Of the many documented tinnitus animal behavioral paradigms, the acoustic startle reflex had been pro- posed as a simple method to identify the presence or absence of tinnitus. Several behavioral models based on conditioned re- sponse suppression paradigms have also been developed. In addition to determining the presence or absence of tinnitus, some of the behavioral paradigms have provided signs of the onset, frequency, and intensity of tinnitus in animals. Although none of these behavioral models have been proved to be a perfect model, these studies provide useful information on understanding the neural mechanisms underlying tinnitus.

关 键 词：TINNITUS Behavioral model Acoustic startle Noise exposure SALICYLATE 

分 类 号：R764.45[医药卫生—耳鼻咽喉科] R-332[医药卫生—临床医学]