THE COCHLEAR AMPLIFIER:IS IT HAIR BUNDLE MOTION OF OUTER HAIR CELLS?  

作　　者：LI Yi He David Z 

机构地区：[1]Department of Otolaryngology-Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University [2]Department of Biomedical Sciences,Creighton University School of Medicine,Omaha,Nebraska,USA

出　　处：《Journal of Otology》2014年第2期64-72,共9页中华耳科学杂志（英文版）

摘　　要：Cochlear outer hair cells （OHCs） are involved in a mechanical feedback loop in which the fast somatic motility of OHCs is required for cochlear amplification. Alternatively, amplification is thought to arise from active hair bundle movements ob- served in non-mammalian hair cells. We measured the voltage-evoked hair bundle motions in the gerbil cochlea to determine if such movements are also present in mammalian OHCs. The OHCs displayed a large hair bundle movement that was not based on mechanotransducer channels but based on somatic motility. Significantly, bundle movements were able to generate radial motion of the rectorial membrane in situ. This result implies that the motility-associated hair bundle motion may be part of the cochlear amplifier.Cochlear outer hair cells （OHCs） are involved in a mechanical feedback loop in which the fast somatic motility of OHCs is required for cochlear amplification. Alternatively, amplification is thought to arise from active hair bundle movements ob- served in non-mammalian hair cells. We measured the voltage-evoked hair bundle motions in the gerbil cochlea to determine if such movements are also present in mammalian OHCs. The OHCs displayed a large hair bundle movement that was not based on mechanotransducer channels but based on somatic motility. Significantly, bundle movements were able to generate radial motion of the rectorial membrane in situ. This result implies that the motility-associated hair bundle motion may be part of the cochlear amplifier.

关 键 词：OHC THE COCHLEAR AMPLIFIER 

分 类 号：R764[医药卫生—耳鼻咽喉科]