糖尿病性视网膜病变与微量白蛋白尿的关系研究  

Relationship between diabetic retinopathy and microalbuminuria

作　　者：刘苹苹[1] 叶宏晖 赵晓静[1] 

机构地区：[1]中山大学附属第五医院眼科,珠海519000

出　　处：《中华眼科医学杂志（电子版）》2014年第5期21-23,共3页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

摘　　要：目的探讨糖尿病性视网膜病变(DR)与微量白蛋白尿的关系。方法收集2013年7月至2014年6月中山大学附属第五医院眼科收治的367例(734只眼)Ⅱ型糖尿病患者的临床资料。根据有无DR及病变程度将患者分为3组:无DR组231例(462只眼)、非增生期DR组117例(234只眼)和增生期DR组19例(38只眼),每组各122例(244只眼)。同时所有患者均留取24 h尿标本作24 h尿微量白蛋白定量检查。患者24 h尿微量白蛋白定量以均数±标准差(x珋±s)的形式表示,并采用单因素方差分析的方法进行组间比较;当差异有统计学意义时进一步采用SNK法进行组间的两两比较。结果无DR组患者24 h尿微量白蛋白定量为(16.15±3.27)mg/L,非增生期DR组患者24 h尿微量白蛋白定量为(61.40±11.74)mg/L,增生期DR组患者24 h尿微量白蛋白定量为(272.37±34.31)mg/L,3组患者比较,差异有统计学意义(W=235.67,P<0.05)。非增生期DR组患者与无DR组患者比较,差异有统计学意义(t=-2.06,P<0.05);增生期DR组患者与无DR组患者比较,差异有统计学意义(t=-2.23,P<0.05);增生期DR组患者与非增生期DR组患者比较,差异有统计学意义(t=-2.71,P<0.05)。结论糖尿病患者出现微量白蛋白尿时应尽快进行眼底检查,对及时发现DR的发生和发展有着重要的临床意义。Objective To assess the relationship between diabetic retinopathy and ,nicroalbuminuria. Methods A total of 367 patients （734 eyes） with type II diabetic mellitus were recruited Department of Ophthalmology, Sun Yat-sen University-Affiliated Fifth Affiliated Hospital consecutively between July,2013 and June,2014. They were divided into 3 groups：non-diabetic retinopathy group （ NDR, n = 231 ）, non-proliferative diabetic retinopathy group （ NPDR, n= 117 ）, and proliferative diabetic retinopathy group （ PDR, n = 19 ）. Urine samples were collected from all patients within the first 24 h of their hospitalization. Urinary albumin was quantitated. Data were analyzed by one ANOVA and Student-Newman- Keuls test. Results The 24 h urinary albumin concentration was significantly higher in NPDR group （61.40±11.74 mg/L） and PDR group （272.37±34.31 mg/L） than in NDR group （16.15±3.27 rag/L） （P 〈 0. 01 ）. Conclusion Microalbuminuria is closely associated with diabetic retinopathy. Early measurement of urinary albumin has significant clinical implications in the early identification of diabetic retinopathy.

关 键 词：糖尿病性视网膜病变 微量白蛋白尿 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]