2,3-二氯-5-甲基吡啶的新合成工艺研究  

A Novel Synthetic Process of 2, 3-Dichloro-5-methylpyridine

作　　者：郑旺[1] 杜晓华[1] 

机构地区：[1]浙江工业大学催化加氢中心浙江省绿色农药清洁生产技术研究重点实验室,浙江杭州310014

出　　处：《浙江化工》2015年第6期7-9,共3页Zhejiang Chemical Industry

摘　　要：[目的]研发一种采用vilsmeier试剂环化合成2,3-二氯-5-甲基吡啶的方法。[方法]以苄胺、丙醛为原料,经缩合、酰化和环化3步反应合成目标产物。[结果]三步反应总收率为46.8%以上,产品含量为98.6%。[结论]该方法原料廉价易得、操作简单、反应条件温和,具有工业化应用前景。[Aims] Explored a novel synthesis of 2,3-dichloro-5-methylpyridine using Vilsmeier reagent.[Methods] 2,3-dichloro-5-methylpyridine was synthesized from benzylamine and propionaldehyde via 3 steps comprising condensation, acylation and cyclization. [Results] The total yield of the three synthetic steps was more than 46.8% and the product purity reached 98.6%. [Conclusions] The improved method has such advantages as cheap and readily available raw materials, simple operations and warm reacting conditions, which is valuable for industrial application.

关 键 词：Vilsmeier试剂 2 3-二氯-5-甲基吡啶 合成 

分 类 号：TQ253.2[化学工程—有机化工]