苦参水提物对湿疹豚鼠皮肤炎症肿胀度的影响研究  

The Effect of Sophora Flavescens Extract on the Skin Swelling of Guinea Pigs with Chronic Eczema

作　　者：张丽华[1] 陈燕[2] 

机构地区：[1]佛山科学技术学院组胚教研室,广东佛山528000 [2]广东省第二人民医院药学部,广东广州510317

出　　处：《中国医药指南》2015年第18期38-39,共2页Guide of China Medicine

基　　金：佛山市医学类科技攻关项目"氧化苦参碱脂质体外用凝胶制备及其抗湿疹药效研究"(201308122);广东省医学科研基金立项项目(A2014706);广东省中医药局建设中医药强省立项资助项目(20141007);广东省医院药学研究基金(奥赛康基金)立项项目(2015A02)

摘　　要：目的通过观察苦参水提物对湿疹豚鼠皮肤炎症肿胀度的抑制作用,探讨其抗炎作用,为临床治疗提供依据。方法豚鼠40只,用2,4-二硝基氯苯在豚鼠颈背部涂抹致敏,在右耳内侧激发造模。随机分成5组,每组8只,分别作为模型对照组、阳性对照组、苦参提取液高、中、低浓度组,对湿疹部位皮肤连续涂抹给药14 d,取双耳等面积的同部位,比较重量,以左、右耳重量之差来评价皮肤炎症肿胀度。结果与模型对照组相比,苦参水提物高、中浓度组豚鼠皮肤肿胀度明显减轻,差异有统计学意义(P<0.05),与阳性对照组比较,苦参水提物高浓度组的豚鼠皮肤肿胀度明显减轻,差异有统计学意义(P<0.05)。结论苦参水提物减少了湿疹豚鼠皮肤的炎性反应,对湿疹的治疗有一定意义。Objective To investigate the inhibition of the swelling of Sophora flavescens extract on the eczema skin,exploring the effect of the antiinflammatory,and to provide the basis for clinical treatment. Method Chronic eczema model of 40 guinea pigs was set up by 2,4-dinitrochlorobenzene sensitizing and exciting, which was randomly divided into model group,positive group and high,medium,low concentration group of sophora flavescens, with 8 enriettii for each group. Eczema skin was continuously administered drugs for 14 days. Lastly, the same part with equal area of each ear was taken and weighed.The difference between the left and right ears was used to evaluate swelling. Result Compared with model group, the high and medium concentration group of sophora flavescens could reduce the swelling on the eczema（P〈 0.05）. The swelling of high dose group was less than the positive group（P 0.05）. Conclusion Sophora flavescens extract decrease the inflammation on the eczema skin, and has some meaning for the treatment of eczema.

关 键 词：苦参 湿疹 肿胀度 水提物 抗炎作用 

分 类 号：R282.710.3[医药卫生—中药学]