Charcot神经性骨关节病急性期炎症指标与骨转换率的相关性分析  

The correlation between inflammatory markers and bone turnover markers in acute Charcot neuro-osteoarthropathy

作　　者：陈炳豪[1] 宋卫东[1] 

机构地区：[1]中山大学孙逸仙纪念医院骨科,广州510080

出　　处：《岭南现代临床外科》2015年第3期311-315,共5页Lingnan Modern Clinics in Surgery

基　　金：广东省科技计划社会发展项目(2011B031800217)

摘　　要：目的探讨Charcot神经性骨关节病(CNO)急性期患者临床检验中炎症指标与骨转换率的相关性。方法对2010年1月至2014年12月在我院住院的15例确诊为CNO急性期的患者进行回顾性分析,记录患者入院时炎症指标及骨转换指标,分析两者之间的相关性。结果CNO患者血清TNF-α以及多项成骨及骨吸收指标均有上升,且TNF-α与β-胶原降解产物(β-crosslaps)、N端骨钙素(N-MID.Os)、总I型胶原氨基端前肽(PINP)以及骨碱性磷酸酶(BALP)均成正相关;IL-10与N-MID.Os、PINP及BALP均成负相关;IL-6、IL-8及IL-1β与骨转换指标没有明显相关性。结论 CNO患者血清中TNF-α与多项骨转换指标的异常提示炎症性关节病的存在及骨代谢的紊乱,成骨及破骨活性均增强。TNF-α与多项骨转换指标相关,该相关性可能特异存在于炎症性骨关节病中,可能为CNO的早期诊断提供一定的价值。Objective To investigate the correlation between serum level of inflammatory markers and serum level of bone turnover markers in patients with acute Charcot neuro-osteoarthropathy（CNO）. Methods Data of 15 patients with acute CNO in our hospital from January 2010 to December2014 was retrospectively analyzed. Serum level of inflammatory markers and bone turnover markers were recorded and correlation analyses were conducted. Results Levels of serum TNF-α, β-crosslaps, N-MID osteocalcin（N-MID.Os）, procollagen type I amino-terminal propeptide（PINP） and bone alkaline phosphatase（BALP） were increased in acute CNO patients. Serum TNF-α was positively correlated to β-crosslaps, N-MID.Os, PINP and BALP, while IL-10 was negatively correlated to NMID.Os, PINP and BALP. In addition, IL-6, IL-8 and IL-1β were not associated with bone turnover markers. Conclusion The abnormal level of TNF-α and bone turnover markers in acute CNO patients revealed inflammatory joint disease with bone metabolism derangement. The correlationship of TNF- αand bone turnover markers might specifically be found in acute CNO patients, which could be valuable in early clinical diagnosis of CNO.

关 键 词：Charcot神经性骨关节病 炎症 骨转换 相关性分析 

分 类 号：R684[医药卫生—骨科学]