格氏反应制备醇实验的改进  

Improvement of Alcohol Preparation Experiment by Grignard Reaction

作　　者：梁冉[1] 张佳[1] 冯玉玲[1] 孙京国[1] 

机构地区：[1]河北师范大学化学与材料科学学院

出　　处：《化学教育》2015年第10期25-28,共4页Chinese Journal of Chemical Education

基　　金：河北师范大学第12批教学改革项目(2012-41);河北师范大学2011年实验教学与管理改革项目(2011-6)

摘　　要：对有机化学必修实验＂格氏反应制备醇＂进行了研究。采用四氢呋喃（THF）替代无水乙醚做反应溶剂,对教材中实验的试剂无水处理、反应的引发、试剂的用量、反应的后处理、产品的重结晶及用薄层色谱（TLC）检测产品纯度等进行了探讨和改进。结果表明,在THF中进行格氏反应制备三苯甲醇,实验现象明显,产率较高,降低了实验成本,全面提高了学生综合实验能力。Preparing alcohol by Grignard reaction,a compulsory organic chemistry experiment in university,was studied in this article.Tetrahydrofuran（THF）was selected as the solvent to substitute absolute ether,the non-aqueous processing of reagents,the initiation of Grignard reaction,the dosage of reagents,the post-processing of the reaction,the recrystallization of products and the purity testing of products conducted by thin layer chromatography（TLC）were discussed and improved.The experimental results showed that preparing triphenyl methanol by Grignard reaction in THF reduced the experiment cost significantly,the experiment phenomena were clear with a high yield,and the students′comprehensive experimental abilities were also improved.

关 键 词：格氏反应 四氢呋喃 三苯甲醇 实验改进 

分 类 号：O625.34-4[理学—有机化学] G642[理学—化学]