悬灸预防含伊立替康化疗方案所致延迟性腹泻临床观察  

Clinical Observation of Suspended Moxibustion on Delayed Diarrhea due to Chemotherapy Regimen Containing Irinotecan

作　　者：应坚[1] 苟春雁 

机构地区：[1]重庆市中医院,重庆400021

出　　处：《中国中医急症》2015年第5期794-796,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：重庆市科委自然基金课题(cstc2011jjA10094)

摘　　要：目的探讨悬灸对预防伊立替康化疗所致延迟性腹泻的临床疗效和安全性。方法 60例患者随机分为艾灸＋化疗组（观察组）和单纯化疗组（对照组）各30例。观察组在接受含伊立替康化疗方案（FOLFIRI）基础上,选取双侧天枢穴﹑足三里穴﹑神阙穴,进行悬灸,每穴施灸10 min,化疗前1 d开始,每日1次,7次为1个疗程,共1疗程。对照组不予以预防性处理,单纯接受FOLFIRI方案化疗。观察延迟性腹泻的发生率,骨髓抑制情况,化疗计划推迟情况。结果观察组发生迟发性腹泻发生率26.67%和严重腹泻发生率6.67%分别低于对照组的46.67%和13.33%（均P〈0.05）。观察组化疗疗程改变发生率13.33%低于对照组的26.67%（P〈0.05）。观察组化疗后发生骨髓抑制情况发生率33.33%和3~4级严重骨髓抑制率6.67%亦低于对照组的50.00%和16.67%（P〈0.05）。观察组施灸过程中无明显不适发生。结论悬灸神阙、天枢和足三里对于预防含有伊立替康化疗方案所致迟发性腹泻有效,安全方便,且能减少化疗后骨髓抑制,降低化疗方案不能顺利实施的发生率。Objective： To study the clinical therapeutic effect and safety of suspended moxibustion in preventing delayed diarrhea due to chemotherapy regimen containing irinotecan. Methods： 60 cases were divided into 2groups randomly including 30 cases in moxibustion and chemotherapy group as the observation group while 30 cases in chemotherapy group as the control group. The observation group were treated with suspended moxibustion on acupoints Tianshu（ST25）,Zusanli（ST36） and Shenque（RN8） of both sides based on FOLFIRI regimen. Each acupoint was moxibusted for 10 minutes from 1 day before chemotherapy. The treatment was given once daily,7days as 1 course. The observation group were treated for 1 course of treatment. The control group were received chemotherapy of FOLFIRI regimen without preventive treatment. There were some indicators being observed such as the incidence,the myelosuppression and the delay of chemotherapy regimen of delayed diarrhea. Results： The incidence of delayed diarrhea and serious diarrhea of the observation group was 26.67% and 46.68% respectively while that of the control group was 46.68% and 13.3% respectively. The incidence of delayed diarrhea and serious diarrhea of the observation group was lower than that of the control group（P〈0.05）. There were 4 cases delayed and the incidence was 13.33% in chemotherapy course in the observation group while there were 8 cases delayed and the incidence was 26.67% in the control group. There were no case interrupted in chemotherapy course of the observation group while there was 1 case interrupted of the control group. The incidence of treatment course changes of the observation group was lower than that of the control group（P〈0.05）. The incidence of myelosuppression of the observation group was 33.33% while that of the control group was 50.0%. The incidence of myelosuppression of the observation group was lower than that of the control group（P〈0.05）. Conclusion： Suspended moxibustion on Tianshu（ST25）,Zusanli（ST36）

关 键 词：延迟性腹泻 悬灸 伊立替康 

分 类 号：R245.8[医药卫生—针灸推拿学]