Efficacy-oriented compatibility for component-based Chinese medicine  

作　　者：Jun-hua ZHANG Yan ZHU Xiao-hui FAN Bo-li ZHANG 

机构地区：[1]Tianjin State Key Laboratory of Modem Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China [2]pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China [3]Chinese Academy of Chinese Medical Science,Beijing 100700, China

出　　处：《Acta Pharmacologica Sinica》2015年第6期654-658,共5页中国药理学报（英文版）

摘　　要：Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and ＂polypills＂, as the frontier in new drug development. A traditional Chinese medicine （TCM） prescription that is usually composed of several medicinal herbs can serve a typical representative of compound medicines. Although the traditional compatibility theory of TCM cannot be well expressed using modern scientific language nowadays, the fundamental purpose of TCM compatibility can be understood as promoting efficacy and reducing toxicity. This paper introduces the theory and methods of efficacy-oriented compatibility for developing component-based Chinese medicines.Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and ＂polypills＂, as the frontier in new drug development. A traditional Chinese medicine （TCM） prescription that is usually composed of several medicinal herbs can serve a typical representative of compound medicines. Although the traditional compatibility theory of TCM cannot be well expressed using modern scientific language nowadays, the fundamental purpose of TCM compatibility can be understood as promoting efficacy and reducing toxicity. This paper introduces the theory and methods of efficacy-oriented compatibility for developing component-based Chinese medicines.

关 键 词：efficacy-oriented compatibility component-based Chinese medicine traditional Chinese medicine multi-target drug 

分 类 号：S859.796[农业科学—临床兽医学] TP311.52[农业科学—兽医学]