Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage： a systematic review and meta-analysis  

作　　者：Hui-qin LI Jing-jing WEI Wan XIA Ji-huang LI Ai-ju LIU Su-bing YIN Chert WANG Liang SONG Yan WANG Guo-qing ZHENG Ji-ping FAN 

机构地区：[1]Department of Neurology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China [2]Department of Cardiology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University,Wenzhou 325027, China [3]China Academy of Chinese Medical Sciences, Beijing 100700, China

出　　处：《Acta Pharmacologica Sinica》2015年第6期659-675,共17页中国药理学报（英文版）

基　　金：This project was supported by the National Natural Science Foundation of China （81173395/H2902）; the young and middle-aged university discipline leaders of Zhejiang province, China （2013277）; the Project of Wenzhou Municipal Science and Technology Bureau in Zhejiang province （Y20110031）; and the Administration of Traditional Chinese Medicine of Zhejiang Province （2011ZB094）.

摘　　要：Aim： To conduct a systematic review and meta-analysis to assess the current evidence available regarding the promoting blood circulation and removing blood stasis （PBCRBS） therapy for Chinese patients with acute intracerebral hemorrhage （ICH）. Methods： Six databases were searched from their inception to November 2013. The studies assessed in ≥4 domains with ＇yes＇ were selected for detailed assessment and meta-analysis. The herbal compositions for PBCRBS therapy for acute ICH patients were also assessed. Results： From the 6 databases, 292 studies claimed randomized-controlled clinical trials （RCTs）. Nine studies with 798 individuals were assessed in ≥4 domains with ＇yes＇ by using the Cochrane RoB tool. Meta-analysis showed that PBCRBS monotherapy and adjuvant therapy for acute ICH could improve the neurological function deficit, reduce the volume of hematoma and perihematomal edema, and lower the mortality rate and dependency. Moreover, there were fewer adverse effects when compared with Western conventional medication controls. Xueshuantong Injection and Fufang Danshen Injection, Buyang Huanwu Decoction and Liangxue Tongyu formula, and three herbs （danshen root, sanqi and leech） were the most commonly used Chinese herbal patent injections, herbal prescriptions and single herbs, respectively. Conclusion： Despite the apparently positive findings, it is premature to conclude that there is sufficient efficacy and safety of PBCRBS for ICH because of the high clinical heterogeneity of the included studies and small number of trials in the meta-analysis. Further large sample-sizes and rigorously designed RCTs are needed.Aim： To conduct a systematic review and meta-analysis to assess the current evidence available regarding the promoting blood circulation and removing blood stasis （PBCRBS） therapy for Chinese patients with acute intracerebral hemorrhage （ICH）. Methods： Six databases were searched from their inception to November 2013. The studies assessed in ≥4 domains with ＇yes＇ were selected for detailed assessment and meta-analysis. The herbal compositions for PBCRBS therapy for acute ICH patients were also assessed. Results： From the 6 databases, 292 studies claimed randomized-controlled clinical trials （RCTs）. Nine studies with 798 individuals were assessed in ≥4 domains with ＇yes＇ by using the Cochrane RoB tool. Meta-analysis showed that PBCRBS monotherapy and adjuvant therapy for acute ICH could improve the neurological function deficit, reduce the volume of hematoma and perihematomal edema, and lower the mortality rate and dependency. Moreover, there were fewer adverse effects when compared with Western conventional medication controls. Xueshuantong Injection and Fufang Danshen Injection, Buyang Huanwu Decoction and Liangxue Tongyu formula, and three herbs （danshen root, sanqi and leech） were the most commonly used Chinese herbal patent injections, herbal prescriptions and single herbs, respectively. Conclusion： Despite the apparently positive findings, it is premature to conclude that there is sufficient efficacy and safety of PBCRBS for ICH because of the high clinical heterogeneity of the included studies and small number of trials in the meta-analysis. Further large sample-sizes and rigorously designed RCTs are needed.

关 键 词：acute intracerebral hemorrhage traditional Chinese medicine promoting blood circulation for removing blood stasis systematic review META-ANALYSIS 

分 类 号：S853.23[农业科学—临床兽医学] Q813[农业科学—兽医学]