Healing Effects of Omalizumab in a Patient with Cholinergic Urticaria Associated Severe Dyspeptic Complaints  

作　　者：Ali Kutlu Alpaslan Tanoglu Sami Ozturk 

机构地区：[1]Department of Immunologv and Allerqy, GATA Haydarpasa Training Hospital, 34668 Uskudar, Istanbul, Turkey [2]Department of Gastroenterology, GATA Haydarpasa Training Hospital, 34668 Uskudar, Istanbul, Turkey

出　　处：《Chinese Medical Journal》2015年第11期1559-1560,共2页中华医学杂志（英文版）

摘　　要：To the Editor： Cholinergic urticaria （CU） is a type of physical urticaria characterized by a number of short-lasting, highly pruritic weals. The underlying pathological mechanism of CU is not fully understood. Omalizumab is a humanized, monoclonal IgG anti-lgE antibody that binds specifically to circulating lgE molecules, thus interrupting the allergic cascade, The efficacy of anti-lgE treatment has been shown in many disorders with complex and unclear etiology, comprising physical urticarias, chronic idiopathic urticaria, angioedema and eosinophil-associated gastrointestinal disorders.To the Editor： Cholinergic urticaria （CU） is a type of physical urticaria characterized by a number of short-lasting, highly pruritic weals. The underlying pathological mechanism of CU is not fully understood. Omalizumab is a humanized, monoclonal IgG anti-lgE antibody that binds specifically to circulating lgE molecules, thus interrupting the allergic cascade, The efficacy of anti-lgE treatment has been shown in many disorders with complex and unclear etiology, comprising physical urticarias, chronic idiopathic urticaria, angioedema and eosinophil-associated gastrointestinal disorders.

分 类 号：S858.287.5[农业科学—临床兽医学] TQ463[农业科学—兽医学]