右美托咪定用于预防手术全麻后寒战的剂量研究  

Dexmedetomidine dosage for treating chilling in patients with minimally uterine laparoscopic surgery after general anesthesia

作　　者：陈丽蓉[1,2] 唐红艳[1,2] 

机构地区：[1]川北医学院附属第二医院 [2]四川绵阳四○四医院麻醉科,四川绵阳621000

出　　处：《热带医学杂志》2015年第5期652-654,683,共4页Journal of Tropical Medicine

摘　　要：目的探讨右美托咪定应用剂量对于子宫肌瘤腹腔镜患者预防全身麻醉后寒战的影响效果。方法选取2012年2月至2014年2月在四川绵阳四○四医院接受治疗的子宫肌瘤腹腔镜患者200例,将患者随机分为4组(各50例),麻醉前30 min分别注射0.9%的生理盐水、右美托咪定0.5、0.75、1.0μg/kg,观察四组患者注射后的寒战发生情况、各时间点体温和心率及VAS疼痛评分。结果在寒战发生率、心率和VAS评分方面,0.75μg/kg组明显低于其它三组,差异均有统计学意义(P<0.05)。体温方面,拔管后和入麻醉检测治疗室后30 min,0.5μg/kg组、0.75μg/kg组和1.0μg/kg组与生理盐水组相比均具有统计学意义(P<0.05)。结论麻醉诱导前注射剂量为0.75μg/kg的右美托咪定,对于子宫肌瘤腹腔镜患者来说减轻了全身麻醉后的寒战反应,降低了患者术中的体温和心率,有效缓解了疼痛。Objective To study dexmedetomidine dosage for treating chilling in patients with minimally uterine fibroid surgery after general anesthesia. Methods 200 cases of patients with minimally uterine fibroid surgery in our hospital were selected for the study from February in 2012 to February in 2014, and randomly divided into four groups（50 cases each）. 30 minutes before anesthesia, patients were injected with 0.9% saline, or with dexmedetomidine of 0.5 μg / kg,1.0 μg / kg, or 0.75 μg / kg. The chilling incidence, body temperature and heart rate of each time point, and VAS pain score of patients after injection were observed. Results The incidence rate of chilling, heart rates and VAS score of0.75 μg / kg group were significantly lower than those in other three groups, statistical significance was founded among four groups（P〈0.05）. The body temperatures of the dexmedetomidine treatment groups were significantly different from that of the saline group（P 〈0.05）. Conclusion The application of 0.75 g / kg dexmedetomidine before anesthesia for patients with minimally uterine fibroid surgery can reduce chilling reaction after general anesthesia, reduce the body temperature and heart rate of patients, and effectively relieve the pain.

关 键 词：子宫肌瘤 腹腔镜 全身麻醉 寒战 右美托咪定 应用剂量 

分 类 号：R614.2[医药卫生—麻醉学]