梅州地区11036例妇女人乳头瘤病毒感染状况及分型的研究  

Human papillomavirus infection and distribution of genotypes of 11 036 women in Meizhou area

作　　者：吴艳丽[1] 苏鲁贤[1] 郑志远[1] 

机构地区：[1]梅州市人民医院检验科,广东梅州514000

出　　处：《热带医学杂志》2015年第5期664-666,共3页Journal of Tropical Medicine

摘　　要：目的探讨梅州地区妇女人乳头瘤病毒（HPV）感染的状况和基因型的分布情况,为该地区宫颈疾病的防治及流行病学研究提供相关的数据资料。方法采用凯普医用核酸分子快速导流杂交基因芯片技术,采集宫颈脱落细胞标本进行HPV检测及基因分型,分析HPV在该地区妇女中感染的状况及其分布规律。结果 11 036例标本中检测出HPV阳性者1 510例,总阳性率为13.68%,其中HR-HPV阳性率为10.69%,以HPV16、HPV52、HPV58和HPV18为主;LR-HPV1.55%,以HPV CP8304和HPV11型多见;各年龄组HPV总感染率居前3位的依次是41~岁（5.42%）,31~岁（4.32%）,51~岁（1.90%）。结论梅州地区妇女HPV感染常见基因型别与亚洲人群分布规律存在一致性,但具有一定的区域特性,不同年龄组HPV感染率差异有统计学意义（P〈0.05）。Objective To study infection and genotypes of human papillomavirus（HPV） in the area of Meizhou, and provide basis for therapy and epidemiology research. Methods A total of 11036 women of Meizhou were selected for study and deciduous cells of cervix uteri were collected. The deciduous cells samples of cervix uteri were used to detect the genotype of HPV by flow-through hybridization technique. Results 1510 patients were infected with HPV out of11036 samples（13.68%）. The rates of high-risk HPV and low-risk HPV were 12.13% and 1.55%, respectively. The major genotype of high-risk HPV were HPV 16, HPV52, HPV58 and HPV18, and the major of low-risk HPV were HPV CP8340 and HPV11. Top three of the age group in the HPV-positive women were 41-50 years old（5.42%）, 31-40 years old（4.32%） and 51-60 years old（1.90%）. Conclusion The distribution characteristic of HPV genotype among women in Meizhou was similar to other areas of Asia, and also has its own character. The distribution was significantly different in different age groups. Therefore HPV infection should be given high attention in gynecological disease, and offered important assistance for disease of uterine cervix prevention and cure.

关 键 词：人乳头瘤病毒 基因分型 宫颈疾病 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]