血清25羟维生素D_3与冠状动脉狭窄程度相关性研究  

Correlation between serum 25-hydroxyvitamin D_3 concentration and the degree of coronary artery stenosis

作　　者：李晖[1] 李明霞[2] 张源明[3] 刘永兵[4] 高翠荣[5] 李雅丽[1] 

机构地区：[1]新疆医科大学第一附属医院VIP内科三病区,乌鲁木齐830054 [2]新疆乌鲁木齐市血液中心质控科,乌鲁木齐830011 [3]新疆医科大学第一附属医院心脏中心高血压科,乌鲁木齐860054 [4]新疆医科大学护理学院,乌鲁木齐830054 [5]新疆医科大学第一附属医院风湿科,乌鲁木齐830054

出　　处：《中华实用诊断与治疗杂志》2015年第6期565-567,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(81160039)

摘　　要：目的探讨血清25羟维生素D3[（25-hydroxyvitamin D3,25（OH）D3）]与冠状动脉狭窄程度的相关性。方法 416例疑似冠心病或冠心病患者,均行冠状动脉造影检查,采用ELISA法检测血清25（OH）D3水平,将所有患者血清25（OH）D3水平按四分位数分为4组,分别为Q1组、Q2组、Q3组和Q4组,比较4组一般资料和Gensini积分;根据冠状动脉是否狭窄分为狭窄组和未狭窄组,比较2组血清25（OH）D3水平,分析血清25（OH）D3水平与冠状动脉狭窄程度的相关性。结果冠状动脉狭窄组血清25（OH）D3水平[（10.64±7.82）μg/L]低于对照组[（12.40±8.77）μg/L],差异有统计学意义（P〈0.05）;Q1组、Q2组、Q3组Gensini积分（6.09±1.32、6.59±1.66、4.30±1.23）高于Q4组（0.93±0.32）（P〈0.05）;25（OH）D3与C反应蛋白水平（r=-0.141,P=0.004）和Gensini评分（r=-0.150,P=0.002）呈负相关;多因素logistic回归分析结果显示,年龄、C反应蛋白、吸烟是冠状动脉狭窄的相关危险因素（OR=1.056,95%CI：1.034-1.079,P=0.000;OR=1.262,95%CI：1.139-1.398,P=0.000;OR=1.036,95%CI：1.016-1.056,P=0.000）;25（OH）D3是冠状动脉狭窄的独立保护因素（OR=0.951,95%CI：0.920-0.983,P=0.003）。结论低水平25（OH）D3与冠状动脉狭窄程度相关。Objective To explore the correlation between serum 25-hydroxyvitamin D3（25（OH）D3）and the degree of coronary artery stenosis.Methods A total of 416 patients underwent coronary angiography,and were detected serum 25（OH）D3level by ELISA.All patients were divided into Q1,Q2,Q3 and Q4groups according to 25（OH）D3levels by the quartile method.The clinical data and Gensini scores were compared among four groups.All the patients were divided into stenosis group and non-stenosis group,and the serum 25（OH）D3levels were compared between two groups.The correlation was analyzed between 25（OH）D3and the degree of coronary artery stenosis.Results The 25（OH）D3level was significantly lower in stenosis group（（10.64±7.82）μg/L）than that in control group（（12.40±8.77）μg/L）（p〈0.05）.The Gensini score was higher in Q1group（6.09±1.32）,Q2group（6.59±1.66）and Q3group（4.30±1.23）than that in Q4group（0.93±0.32）（p〈0.05）.The 25（OH）D3level was negatively correlated with C-reactive protein（r=-0.141,P=0.004）and Gensini score（r=-0.150,P=0.002）.Multivariable logistic regression analysis results showed that age,C-reactive protein and smoking were the related risk factors for coronary artery stenosis（OR=1.056,95%CI：1.034 to 1.079,P=0.000;OR=1.262,95%CI：1.139 to 1.398,P=0.000;OR=1.036,95%CI：1.016to1.056,P=0.000）.25（OH）D3was the independent protective factor of coronary artery stenosis（OR=0.951,95%CI：0.920 to 0.983,P=0.003）.Conclusion Low serum 25（OH）D3level is correlated with the degree of coronary artery stenosis.

关 键 词：冠心病 25羟维生素D3 冠状动脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]