慢性阻塞性肺疾病急性加重患者肺动脉与主动脉直径比>1和血浆尿钠肽、C反应蛋白、白细胞介素6的相关性分析  

The Relevance of the Ratio of Pulmonary Arterial Diameter to Aortic Diameter Exceeding One with Brain Natriuretic Peptide and Inflammatory Factors in Patients with Acute Exacerbation of COPD

作　　者：张明[1] 彭夏莹 刘守智[1] 梁宗安[1] 

机构地区：[1]四川大学华西医院呼吸与危重症医学科,四川成都610041

出　　处：《中国呼吸与危重监护杂志》2015年第3期255-259,共5页Chinese Journal of Respiratory and Critical Care Medicine

摘　　要：目的探究在慢性阻塞性肺疾病（简称慢阻肺）急性加重患者中，肺动脉主干直径与主动脉直径比值（PA：A）〉1与血浆尿钠肽（BNP）、C反应蛋白（CRP）、白细胞介素6（IL-6）水平的相关性。方法纳入2013年8月至2013年12月于华西医院呼吸与危重症医学科住院治疗的慢阻肺急性加重患者95例，根据PA：A是否〉1分为两组：PA：A〉1组和PA：A≤1组。收集两组患者的基本资料，并检测入院24h内动脉血气分析、血浆BNP、CRP和IL-6水平。结果PA：A〉1组患者血浆BNP水平为483-4582ng／L，中位数为2005ng／L；PA：A≤1组患者血浆BNP水平为137-1224ng／L，中位数为404ng／L，两组患者的血浆BNP水平比较有显著差异（P〈0．01），CRP、IL-6水平差异均无统计学意义。结论在慢阻肺急性加重患者中，PA：A〉1与BNP水平有相关性，但与CRP、IL-6无相关性。Objective To explore the relevance of the ratio of pulmonary arterial diameter to aortic diameter exceeding one （ PA： A 〉 1 ） with brain natriuretic peptide （BNP） and inflammatory factor levels in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods From August 2013 to December 2013,95 inpatients with AECOPD in West China Hospital were divided into two groups according to the ratio of pulmonary arterial diameter to aortic diameter. The clinical data of the patients were collected. Meanwhile ,arterial blood gas ,plasma levels of BNP,C-reactive protein （CRP） , and interleukin-6 （IL-6） within 24 hours were measured. Results The plasma BNP level was 2005 （483 - 4582） ng/L in the group with PA： A 〉 1 ,and 404（ 137 - 1224） ng/L in the group with PA： A 〈 1. There was significant difference in plasma BNP level between two groups （ P 〈 0. O1 ）. There was no significant difference in CRP or IL-6 level between two groups （ P 〉 0. 05 ）. Conclusion The ratio of pulmonary arterial diameter to aortic diameter is correlated with BNP level in patients with AECOPD,but is not correlated with CRP or IL-6.

关 键 词：慢性阻塞性肺疾病 急性加重 肺动脉高压 尿钠肽 

分 类 号：R563.9[医药卫生—呼吸系统]