宿主microRNAs在HCV复制及抗HCV治疗中的作用  

Research advances in micro RNAs in regulating hepatitis C virus replication and antiviral therapy

作　　者：崔祥华[1] 贾继东[1] 

机构地区：[1]首都医科大学附属北京友谊医院肝病中心,北京100050

出　　处：《临床肝胆病杂志》2015年第5期800-802,共3页Journal of Clinical Hepatology

摘　　要：HCV感染是导致慢性肝炎、肝硬化及肝细胞癌(HCC)的主要原因之一。微小RNA(miRNAs)是一类非编码小分子RNA,可参与人体多种生理、病理过程。简述了mi RNAs调控HCV复制的机制,探讨了肝特异性microRNA-122(mi R-122)拮抗剂对丙型肝炎抗病毒治疗的作用。认为miRNAs对HCV的表达起着重要调节作用,有望成为治疗HCV感染的一种措施,但仍需进一步研究。Hepatitis C virus （HCV）infection is one of the most common causes of chronic hepatitis,liver cirrhosis,and hepatocellular car-cinoma.MicroRNAs （miRNAs）,a class of small,non -coding RNA,are involved in a variety of physiological and pathological processes in human bodies.The mechanism by which miRNAs regulate HCV replication is described,and the effects of liver -specific microRNA -122 antagonists on hepatitis C antiviral therapy are discussed.Our study indicates that miRNAs play an important regulatory role in HCV ex-pression.Targeting miRNAs may be a potential therapeutic approach for treating HCV infection,but further studies are still in need.

关 键 词：肝炎病毒属 微RNA 抗病毒药 综述 

分 类 号：R512.63[医药卫生—内科学]