埃博拉疫苗和药物研究进展  

Recent Advances in Vaccines and Drugs Against the Ebola Virus

作　　者：朱祥[1,2] 尧晨光 魏艳红[1,2] 寇铮[1,2] 胡康洪[1,2] 

机构地区：[1]湖北工业大学中德生物医学中心,武汉430068 [2]发酵工程湖北省协同创新中心,武汉430068

出　　处：《病毒学报》2015年第3期287-292,共6页Chinese Journal of Virology

基　　金：湖北工业大学启动基金(Nr.337.193);"十二五"国家科技重大专项项目基金(2012ZX10004503-008)

摘　　要：埃博拉病毒（Ebola virus）是丝状病毒科的一员,可导致埃博拉出血热,致死率达25%~90%不等。2014年暴发的埃博拉疫情席卷了西非各地,极高的致死率引起了全世界的恐慌。鉴于埃博拉病毒严重威胁人类公共健康,科学研究毫无懈怠,多种疫苗如rVSV-ZEBOV和ChAd3-ZEBOV等已经进入临床试验阶段,多种药物如TKMEbola和ZMapp等已用于埃博拉患者的紧急治疗。本文总结了近期埃博拉疫苗和药物的最新研究进展。The Ebola virus belongs to the Filovirus family,which causes Ebola hemorrhagic fever（mortality,25%-90%）.An outbreak of infection by the Ebola virus is sweeping across West Africa,leading to high mortality and worldwide panic.The Ebola virus has caused a serious threat to public health,so intensive scientific studies have been carried out.Several vaccines（e.g.,rVSV-ZEBOV,ChAd3-ZEBOV）have been put into clinical trials and antiviral drugs（e.g.,TKM-Ebola,ZMAPP）have been administered in the emergency setting to patients infected by the Ebola virus.Here,recent advances in vaccines and drugs against the Ebola virus are reviewed.

关 键 词：埃博拉病毒 疫苗 药物 

分 类 号：R373.32[医药卫生—病原生物学]