器官移植病人戊型肝炎病毒慢性化感染及治疗  

Chronic Hepatitis E Virus Infection and Treatment in Organ Transplant Recipients

作　　者：陈书[1] 卫飞雪 吴婷[1] 夏宁邵[1] 

机构地区：[1]厦门大学公共卫生学院,国家传染病诊断试剂与疫苗工程技术研究中心,分子疫苗学和分子诊断学国家重点实验室,厦门361102

出　　处：《病毒学报》2015年第3期293-298,共6页Chinese Journal of Virology

基　　金：国家科技重大专项(2013ZX09101017);国家自然科学基金(81373061);厦门市科技计划项目(3502Z20131001)

摘　　要：戊型肝炎是由戊型肝炎病毒(Hepatitis E virus,HEV)感染引起的急性病毒性肝炎,其发病率居急性病毒性肝炎之首。戊型肝炎通常呈急性感染病程,2008年以来陆续发现器官移植病人等免疫抑制患者感染HEV后可能迁延为慢性化。在无抗病毒药物治疗的情况下,器官移植病人感染HEV后迁延为慢性感染的比例超过60%,其中10%的病人慢性感染HEV后可能出现肝纤维化,并且在较短的时间内进展为失代偿性肝硬化导致死亡。本文简要综述器官移植病人HEV慢性化感染及治疗。Hepatitis E,caused by hepatitis E virus（HEV）infection,usually leads to an acute clinical course,and is the most common diagnosis among cases of acute viral hepatitis.From 2008,there have been increasing reports of chronic HEV infection in immunocompromised patients such as organ transplant recipients.Without intervention with antiviral treatment,approximately 60% of HEV infections in organ transplant recipients evolve into chronic HEV infections.Of these chronic hepatitis E patients,10% may develop liver fibrosis and progress to liver cirrhosis.This article reviews chronic HEV infection and treatment in organ transplant recipients.

关 键 词：戊型肝炎病毒 器官移植 慢性化感染 治疗 

分 类 号：R183.4[医药卫生—流行病学]