呼吸道上皮细胞模型的研究进展  

Research Progress in Airway Epithelial Cell Culture as a Respiratory Disease Model

作　　者：张少丹[1] 李武平[1,2] 

机构地区：[1]中国医学科学院北京协和医学院输血研究所输血传染病中心,成都610052 [2]中国医学科学院北京协和医学院病原生物学研究所卫生部病原系统生物学重点实验室,北京100176

出　　处：《病毒学报》2015年第3期307-312,共6页Chinese Journal of Virology

摘　　要：呼吸道病毒严重威胁人类的健康。呼吸道上皮细胞是机体防御呼吸道病毒和细菌等外来病原体的第一道防线,因此建立呼吸道上皮细胞体外分化模型,为研究呼吸系统疾病发病机理、筛选有效的治疗药物奠定基础。本文主要介绍人呼吸道上皮细胞原代培养技术的研究进展及其在呼吸道病毒和呼吸系统疾病方面的应用。Respiratory virus poses a serious threat to human life and health.Airway epithelial cells are the body＇s first line of defense from a wide variety of foreign pathogens,such as viruses and bacteria.Therefore,successful airway epithelial cell culture can provide a model for investigating the mechanisms underlying respiratory pathogenic diseases following airway virus infection.This respiratory disease model can also be used for the potential development of novel therapeutics.Here we provide a brief review of recent developments on the culture of cells derived from human trachea-bronchial airway epithelium,and the application of this model for studying respiratory virus and disease.

关 键 词：呼吸道上皮细胞 气液界面培养 呼吸道病毒 

分 类 号：R373.9[医药卫生—病原生物学]